Retrospective comparison of two different schedules of irinotecan, 5-fluorouracil and folinic acid in previously untreated patients with advanced colorectal carcinoma: A single institution experience

A. Gluzman, K. Rubinov, W. Mermershtain, S. Man, S. Ariad, K. Lavrenkov

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Purpose: To compare efficacy and tolerability of weekly irinotecan combined with 5-fluorouracil (5-FU) bolus and folinic acid (FA) regimen (IFL) versus biweekly irinotecan with infusional 5-FU and FA (FOLPIRI) in patients (pts) with advanced stage colorectal cancer. Patients and Methods: Treatments outcome of 86 pts (IFL - 38 pts, FOLFIRI - 48 pts) was evaluated. Chemotherapy regimens were as follows: IFL - intravenous (i.v.) infusion irinotecan 125 mg/m 2 over 90 min and 5-FU 500 mg/m2 preceded by FA 20 mg/m2 both given by i.v. bolus injection, all repeated on days 1, 8, 15 and 22 every 6 weeks; FOLFIRI - i.v. irinotecan 180 mg/ m2 on days 1 and 15 with subsequent FA 200 mg/m2 administered as a 2-hour infusion and i.v. bolus injection of 400 mg/m2 5-FU immediately followed by 22-hour i.v. infusion of 600 mg/m2 5-FU on days 1, 2, 15 and 16 every 4 weeks. Treatment continued until disease progression or unacceptable toxicity. Results: A total of 152 (mean - 4) IFL cycles and 328 (mean - 6) FOLFIRI cycles were administered. Average dose intensity was 0.8 and 0.78 respectively. Toxicities were mild and manageable for both regimens evaluated. Overall response rate was 36.8% in IFL arm and 44.7 % in FOLFIRI arm. At the median follow-up of 16 months in IFL arm and 14 months in FOPFIRI arm the two year survival was 38% and 45%, the median survival was 18 months and 21.5 months, and the median progression free survival was 6 months and 9.4 months respectively. Conclusions: In our experience, both IFL and FOLFIRI regimens have acceptable toxicity at a similar level of dose intensity. Compared to IFL, FOLFIRI seems to improve progression-free survival.

Original languageEnglish
Pages (from-to)739-743
Number of pages5
JournalJournal of Chemotherapy
Volume19
Issue number6
DOIs
StatePublished - 1 Jan 2007
Externally publishedYes

Keywords

  • 5-Fluorourocil
  • Colorectal carcinoma
  • Folinic acid
  • Irinotecam

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