Reversal by the MER tubercle bacillus fraction of the suppressive effects of heterologous antilymphocytic serum (ALS) on the allograft reactivity of mice

Oded Kuperman; Mina Feigis; David W. Weiss

doi:10.1016/0008-8749(73)90139-1

Reversal by the MER tubercle bacillus fraction of the suppressive effects of heterologous antilymphocytic serum (ALS) on the allograft reactivity of mice

Oded Kuperman, Mina Feigis, David W. Weiss

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Abstract

Treatment of immunized C57B1 mice with the MER fraction of BCG prevented wholly or in large part the strong immunosuppressive effects elicited by heterologous ALS against allograft reactivity, as measured by the in vitro cytotoxic activity of spleen cells against the immunizing allogeneic cells (a BALB/c plasmacytoma). Moreover, the heightened cytotoxic capacity of spleen cells bestowed by treatment of the donor with MER was manifested in some instances despite exposure to ALS. Spleen cells from MER-treated hosts were also more refractory to the direct cytotoxic action of ALS and complement in vitro.

Original language	English
Pages (from-to)	484-489
Number of pages	6
Journal	Cellular Immunology
Volume	8
Issue number	3
DOIs	https://doi.org/10.1016/0008-8749(73)90139-1
State	Published - 1 Jan 1973
Externally published	Yes

ASJC Scopus subject areas

Immunology

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10.1016/0008-8749(73)90139-1

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title = "Reversal by the MER tubercle bacillus fraction of the suppressive effects of heterologous antilymphocytic serum (ALS) on the allograft reactivity of mice",

abstract = "Treatment of immunized C57B1 mice with the MER fraction of BCG prevented wholly or in large part the strong immunosuppressive effects elicited by heterologous ALS against allograft reactivity, as measured by the in vitro cytotoxic activity of spleen cells against the immunizing allogeneic cells (a BALB/c plasmacytoma). Moreover, the heightened cytotoxic capacity of spleen cells bestowed by treatment of the donor with MER was manifested in some instances despite exposure to ALS. Spleen cells from MER-treated hosts were also more refractory to the direct cytotoxic action of ALS and complement in vitro.",

author = "Oded Kuperman and Mina Feigis and Weiss, {David W.}",

note = "Funding Information: This work was supported by Contract NIH Department of Health, Education and Welfare, tion of Los Angeles, Inc., Mr. and Mrs. Frank 70-2127 from the National Institutes and by research grants from Concern Lautenberg, and the Tisch Circle.",

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T1 - Reversal by the MER tubercle bacillus fraction of the suppressive effects of heterologous antilymphocytic serum (ALS) on the allograft reactivity of mice

AU - Kuperman, Oded

AU - Feigis, Mina

AU - Weiss, David W.

N1 - Funding Information: This work was supported by Contract NIH Department of Health, Education and Welfare, tion of Los Angeles, Inc., Mr. and Mrs. Frank 70-2127 from the National Institutes and by research grants from Concern Lautenberg, and the Tisch Circle.

PY - 1973/1/1

Y1 - 1973/1/1

N2 - Treatment of immunized C57B1 mice with the MER fraction of BCG prevented wholly or in large part the strong immunosuppressive effects elicited by heterologous ALS against allograft reactivity, as measured by the in vitro cytotoxic activity of spleen cells against the immunizing allogeneic cells (a BALB/c plasmacytoma). Moreover, the heightened cytotoxic capacity of spleen cells bestowed by treatment of the donor with MER was manifested in some instances despite exposure to ALS. Spleen cells from MER-treated hosts were also more refractory to the direct cytotoxic action of ALS and complement in vitro.

AB - Treatment of immunized C57B1 mice with the MER fraction of BCG prevented wholly or in large part the strong immunosuppressive effects elicited by heterologous ALS against allograft reactivity, as measured by the in vitro cytotoxic activity of spleen cells against the immunizing allogeneic cells (a BALB/c plasmacytoma). Moreover, the heightened cytotoxic capacity of spleen cells bestowed by treatment of the donor with MER was manifested in some instances despite exposure to ALS. Spleen cells from MER-treated hosts were also more refractory to the direct cytotoxic action of ALS and complement in vitro.

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SN - 0008-8749

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ER -

Reversal by the MER tubercle bacillus fraction of the suppressive effects of heterologous antilymphocytic serum (ALS) on the allograft reactivity of mice

Abstract

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UN SDGs

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