Rewarding effects of AMPA administration into the supramammillary or posterior hypothalamic nuclei but not the ventral tegmental area

Satoshi Ikemoto, Brian M. Witkin, Abraham Zangen, Roy A. Wise

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

We examined whether injections of the excitatory amino acid AMPA are rewarding when injected into the posterior hypothalamus and ventral tegmental area. Rats quickly learned to lever-press for infusions of AMPA into the supramammillary or posterior hypothalamic nuclei but failed to learn to lever-press for similar injections into the ventral tegmental areas. AMPA injections into the supramammillary nucleus, but not the ventral tegmental area, induced conditioned place preference. The rewarding effects of AMPA appear to be mediated by AMPA receptors, because coadministration of the AMPA antagonist CNQX blocked the rewarding effects of AMPA, and administration of the enantiomer R-AMPA did not mimic the rewarding effects. AMPA injections into the supramammillary nucleus, but not the ventral tegmental area, also increased extracellular dopamine concentrations in the nucleus accumbens. Pretreatment with the D1 dopamine antagonist SCH 23390 [R-(+)-7-chloro-8-hydroxy-3-methyl-1- phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine] led to extinction of AMPA self-administration. These findings implicate posterior hypothalamic regions in reward function and suggest that reward mechanisms localized around the ventral tegmental area are more complex than has been assumed recently.

Original languageEnglish
Pages (from-to)5758-5765
Number of pages8
JournalJournal of Neuroscience
Volume24
Issue number25
DOIs
StatePublished - 23 Jun 2004
Externally publishedYes

Keywords

  • Conditioned place preference
  • Dopamine D receptor antagonist
  • Excitatory amino acid
  • Glutamate
  • Intracranial self-administration
  • Microdialysis
  • Nucleus accumbens
  • Reinforcement
  • SCH 23390

ASJC Scopus subject areas

  • Neuroscience (all)

Fingerprint

Dive into the research topics of 'Rewarding effects of AMPA administration into the supramammillary or posterior hypothalamic nuclei but not the ventral tegmental area'. Together they form a unique fingerprint.

Cite this