TY - JOUR
T1 - Rheumatoid arthritis and thyroid dysfunction
T2 - A cross-sectional study and a review of the literature
AU - Mahagna, Hussein
AU - Caplan, Alyssa
AU - Watad, Abdulla
AU - Bragazzi, Nicola Luigi
AU - Sharif, Kassem
AU - Tiosano, Shmuel
AU - Mahroum, Naim
AU - Hendel, Hen
AU - Shoenfeld, Yehuda
AU - Comaneshter, Doron
AU - Cohen, Arnon D.
AU - Amital, Howard
N1 - Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2018/10/1
Y1 - 2018/10/1
N2 - Thyroid dysfunction appears to show increased prevalence in many autoimmune diseases; however, this comorbidity has not been properly investigated in patients with RA. This issue was addressed in this cross-sectional study. Using the database of the Clalit Health Services (CHS) in Israel, RA patients were paired with age- and sex-matched controls to compare the prevalence of hypothyroidism and hyperthyroidism. Chi-squared and t-tests were used for univariate analysis and a logistic regression model was used for multivariate analysis. The study included 11,782 patients with RA and 57,973 controls. The rate of thyroid dysfunction diseases in RA patients was increased compared with the prevalence in controls (16.0% and 11.7%, p < 0.001, for hypothyroidism; and 2.33% and 1.81%, p < 0.001 in hyperthyroidism, respectively). In a multivariate analysis, RA was associated with hypothyroidism (OR = 1.42, 95% CI 1.34–1.50) and hyperthyroidism (OR = 1.26, 95% CI 1.10–1.45). RA is associated with thyroid dysfunction. Therefore, physicians treating patients with RA should be aware of the possibility of comorbid thyroid dysfunction and treat accordingly.
AB - Thyroid dysfunction appears to show increased prevalence in many autoimmune diseases; however, this comorbidity has not been properly investigated in patients with RA. This issue was addressed in this cross-sectional study. Using the database of the Clalit Health Services (CHS) in Israel, RA patients were paired with age- and sex-matched controls to compare the prevalence of hypothyroidism and hyperthyroidism. Chi-squared and t-tests were used for univariate analysis and a logistic regression model was used for multivariate analysis. The study included 11,782 patients with RA and 57,973 controls. The rate of thyroid dysfunction diseases in RA patients was increased compared with the prevalence in controls (16.0% and 11.7%, p < 0.001, for hypothyroidism; and 2.33% and 1.81%, p < 0.001 in hyperthyroidism, respectively). In a multivariate analysis, RA was associated with hypothyroidism (OR = 1.42, 95% CI 1.34–1.50) and hyperthyroidism (OR = 1.26, 95% CI 1.10–1.45). RA is associated with thyroid dysfunction. Therefore, physicians treating patients with RA should be aware of the possibility of comorbid thyroid dysfunction and treat accordingly.
KW - Autoimmune disease
KW - Comorbidity
KW - Hypothyroidism
KW - Rheumatoid arthritis
KW - Thyroid dysfunction
UR - http://www.scopus.com/inward/record.url?scp=85061960576&partnerID=8YFLogxK
U2 - 10.1016/j.berh.2019.01.021
DO - 10.1016/j.berh.2019.01.021
M3 - Article
AN - SCOPUS:85061960576
SN - 1521-6942
VL - 32
SP - 683
EP - 691
JO - Best Practice and Research: Clinical Rheumatology
JF - Best Practice and Research: Clinical Rheumatology
IS - 5
ER -