Rietveld refinement of the cocrystal 2,4-dihy-droxy-benzoic acid-N′-(pro-pan-2-yl-idene)nicotinohydrazide (1/1)

Saul H. Lapidus, Andreas Lemmerer, Joel Bernstein, Peter W. Stephens

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

A further example of using a covalent-bond-forming reaction to alter supra-molecular assembly by modification of hydrogen-bonding possibilities is presented. This concept was introduced by Lemmerer, Bernstein & Kahlenberg [CrystEngComm (2011), 13, 55-59]. The title structure, C9H 11N3O·C7H6O4, which consists of a reacted niazid mol-ecule, viz. N′-(propan-2-yl-idene)nicotinohydrazide, and 2,4-di-hy-droxy-benzoic acid, was solved from powder diffraction data using simulated annealing. The results further demonstrate the relevance and utility of powder diffraction as an analytical tool in the study of cocrystals and their hydrogen-bond inter-actions.

Original languageEnglish
Pages (from-to)o335-o337
JournalActa Crystallographica Section C: Crystal Structure Communications
Volume68
Issue number9
DOIs
StatePublished - 1 Sep 2012
Externally publishedYes

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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