Right prefrontal TMS versus sham treatment of mania: A controlled study

Alex Kaptsan; Yuri Yaroslavksy; Julia Applebaum; Robert H. Belmaker; Nimrod Grisaru

doi:10.1034/j.1399-5618.2003.00003.x

Right prefrontal TMS versus sham treatment of mania: A controlled study

Alex Kaptsan, Yuri Yaroslavksy, Julia Applebaum, Robert H. Belmaker, Nimrod Grisaru

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Abstract

Objective: Left prefrontal transcranial magnetic stimulation (TMS) has been reported to have ECT-like effects in depression and we therefore planned a study of TMS in mania. Sixteen patients completed trial of right versus left prefrontal TMS at 20 Hz, 2-sec duration per train, 20 trains per day for 10 treatment days. Mania was evaluated using the Mania Scale, the Brief Psychiatric Rating Scale and the Clinical Global Impression. Significantly more improvement was observed in patients treated with right prefrontal TMS than with left prefrontal. We now report a follow-up study of right active TMS versus right sham TMS with the same indications and parameters. Methods: Twenty-five patients entered and 19 completed right TMS versus sham right TMS. Results: Right TMS was no more effective than sham TMS. Conclusions: It is possible that the previous results were due to an effect of left TMS to worsen mania. Alternatively, it is noted that the present patient group had much more psychosis than the previous study of TMS in mania, and depression studies have reported that psychosis is a poor prognostic sign for TMS response.

Original language	English
Pages (from-to)	36-39
Number of pages	4
Journal	Bipolar Disorders
Volume	5
Issue number	1
DOIs	https://doi.org/10.1034/j.1399-5618.2003.00003.x
State	Published - 1 Feb 2003

Keywords

Frontal cortex
Mania
TMS transcranial magnetic stimulation

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1034/j.1399-5618.2003.00003.x

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abstract = "Objective: Left prefrontal transcranial magnetic stimulation (TMS) has been reported to have ECT-like effects in depression and we therefore planned a study of TMS in mania. Sixteen patients completed trial of right versus left prefrontal TMS at 20 Hz, 2-sec duration per train, 20 trains per day for 10 treatment days. Mania was evaluated using the Mania Scale, the Brief Psychiatric Rating Scale and the Clinical Global Impression. Significantly more improvement was observed in patients treated with right prefrontal TMS than with left prefrontal. We now report a follow-up study of right active TMS versus right sham TMS with the same indications and parameters. Methods: Twenty-five patients entered and 19 completed right TMS versus sham right TMS. Results: Right TMS was no more effective than sham TMS. Conclusions: It is possible that the previous results were due to an effect of left TMS to worsen mania. Alternatively, it is noted that the present patient group had much more psychosis than the previous study of TMS in mania, and depression studies have reported that psychosis is a poor prognostic sign for TMS response.",

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AU - Applebaum, Julia

AU - Belmaker, Robert H.

AU - Grisaru, Nimrod

PY - 2003/2/1

Y1 - 2003/2/1

N2 - Objective: Left prefrontal transcranial magnetic stimulation (TMS) has been reported to have ECT-like effects in depression and we therefore planned a study of TMS in mania. Sixteen patients completed trial of right versus left prefrontal TMS at 20 Hz, 2-sec duration per train, 20 trains per day for 10 treatment days. Mania was evaluated using the Mania Scale, the Brief Psychiatric Rating Scale and the Clinical Global Impression. Significantly more improvement was observed in patients treated with right prefrontal TMS than with left prefrontal. We now report a follow-up study of right active TMS versus right sham TMS with the same indications and parameters. Methods: Twenty-five patients entered and 19 completed right TMS versus sham right TMS. Results: Right TMS was no more effective than sham TMS. Conclusions: It is possible that the previous results were due to an effect of left TMS to worsen mania. Alternatively, it is noted that the present patient group had much more psychosis than the previous study of TMS in mania, and depression studies have reported that psychosis is a poor prognostic sign for TMS response.

AB - Objective: Left prefrontal transcranial magnetic stimulation (TMS) has been reported to have ECT-like effects in depression and we therefore planned a study of TMS in mania. Sixteen patients completed trial of right versus left prefrontal TMS at 20 Hz, 2-sec duration per train, 20 trains per day for 10 treatment days. Mania was evaluated using the Mania Scale, the Brief Psychiatric Rating Scale and the Clinical Global Impression. Significantly more improvement was observed in patients treated with right prefrontal TMS than with left prefrontal. We now report a follow-up study of right active TMS versus right sham TMS with the same indications and parameters. Methods: Twenty-five patients entered and 19 completed right TMS versus sham right TMS. Results: Right TMS was no more effective than sham TMS. Conclusions: It is possible that the previous results were due to an effect of left TMS to worsen mania. Alternatively, it is noted that the present patient group had much more psychosis than the previous study of TMS in mania, and depression studies have reported that psychosis is a poor prognostic sign for TMS response.

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Right prefrontal TMS versus sham treatment of mania: A controlled study

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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