Risk factors and correlates of protection against XBB SARS-CoV-2 infection among health care workers

Michal Canetti; Noam Barda; Yaniv Lustig; Yael Weiss-Ottolenghi; Victoria Indenbaum; Yovel Peretz; Neta Zuckerman; Keren Asraf; Sharon Amit; Yitshak Kreiss; Gili Regev-Yochay

doi:10.1016/j.vaccine.2024.126308

Risk factors and correlates of protection against XBB SARS-CoV-2 infection among health care workers

Michal Canetti, Noam Barda, Yaniv Lustig, Yael Weiss-Ottolenghi, Victoria Indenbaum, Yovel Peretz, Neta Zuckerman, Keren Asraf, Sharon Amit, Yitshak Kreiss, Gili Regev-Yochay

Department of Software and Information Systems Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

Correlates of protection for recent emerging SARS-CoV-2 variants have not been determined. In this test-negative case-control study, we report lower odds of infection with XBB variants among those boosted during the last six months. Additionally, we demonstrate that XBB-specific neutralizing antibodies are independent correlates of protection.

Original language	English
Article number	126308
Journal	Vaccine
Volume	42
Issue number	26
DOIs	https://doi.org/10.1016/j.vaccine.2024.126308
State	Published - 2 Dec 2024

Keywords

Correlates of protection
COVID-19
Omicron
XBB

ASJC Scopus subject areas

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1016/j.vaccine.2024.126308

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abstract = "Correlates of protection for recent emerging SARS-CoV-2 variants have not been determined. In this test-negative case-control study, we report lower odds of infection with XBB variants among those boosted during the last six months. Additionally, we demonstrate that XBB-specific neutralizing antibodies are independent correlates of protection.",

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AU - Canetti, Michal

AU - Barda, Noam

AU - Lustig, Yaniv

AU - Weiss-Ottolenghi, Yael

AU - Indenbaum, Victoria

AU - Peretz, Yovel

AU - Zuckerman, Neta

AU - Asraf, Keren

AU - Amit, Sharon

AU - Kreiss, Yitshak

AU - Regev-Yochay, Gili

PY - 2024/12/2

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AB - Correlates of protection for recent emerging SARS-CoV-2 variants have not been determined. In this test-negative case-control study, we report lower odds of infection with XBB variants among those boosted during the last six months. Additionally, we demonstrate that XBB-specific neutralizing antibodies are independent correlates of protection.

KW - Correlates of protection

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ER -

Risk factors and correlates of protection against XBB SARS-CoV-2 infection among health care workers

Abstract

Keywords

ASJC Scopus subject areas

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