TY - JOUR
T1 - Risk factors for congenital heart defects in two populations residing in the same geographic area
T2 - A long-term population-based study, Southern Israel
AU - Robinson, Renana
AU - Stavsky, Moshe
AU - Yitshak Sade, Maayan
AU - Krymko, Hanah
AU - Slanovic, Leonel
AU - Novack, Victor
AU - Atar Vardi, Maya
AU - Broides, Arnon
AU - Levitas, Aviva
N1 - Publisher Copyright:
© Cambridge University Press 2019.
PY - 2019/8/1
Y1 - 2019/8/1
N2 - Background: Congenital Heart Defects (CHD) are the most common structural defects of newborns. Southern Israel's population is comprised of Jews (75%) and Arab-Bedouins (25%). The latter has a high rate of consanguinity and low abortion rate compared with the Jewish population, which led us to suspect a higher CHD prevalence in this population. Our aim was to compare maternal risk factors that are associated with CHD in these populations.Methods: All births during 1991-2011 in Soroka University Medical Center (n = 247, 289) with 6078 newborns having CHD were included. To account for same-woman deliveries, general estimating equation models adjusted for ethnicity, gender and birth number were used.Results: The total prevalence of CHD was 24.6/1000 live births, with 21.4 and 30 among Jewish and Bedouin populations, respectively, (p = 0.001). Multi-variant analysis of risk factors for CHD revealed that risk factors common to both populations included conception with fertility medications, sibling CHD, maternal CHD, diabetes mellitus, hypertension and anaemia. Risk factors that were specific for the Bedouin population were - maternal age over 35 years, recurrent pregnancy loss and in vitro fertilisation. However, sibling CHD was more common as a CHD risk factor in the Jewish compared with the Bedouin population (Adjusted OR 10.23 versus 3.19, respectively).Conclusions: The prevalence of CHD is higher in both the Bedouin and Jewish populations than previously reported. Several maternal factors were associated with CHD specifically for a certain population. Risk factors for CHD vary in populations residing in the same geographic area.
AB - Background: Congenital Heart Defects (CHD) are the most common structural defects of newborns. Southern Israel's population is comprised of Jews (75%) and Arab-Bedouins (25%). The latter has a high rate of consanguinity and low abortion rate compared with the Jewish population, which led us to suspect a higher CHD prevalence in this population. Our aim was to compare maternal risk factors that are associated with CHD in these populations.Methods: All births during 1991-2011 in Soroka University Medical Center (n = 247, 289) with 6078 newborns having CHD were included. To account for same-woman deliveries, general estimating equation models adjusted for ethnicity, gender and birth number were used.Results: The total prevalence of CHD was 24.6/1000 live births, with 21.4 and 30 among Jewish and Bedouin populations, respectively, (p = 0.001). Multi-variant analysis of risk factors for CHD revealed that risk factors common to both populations included conception with fertility medications, sibling CHD, maternal CHD, diabetes mellitus, hypertension and anaemia. Risk factors that were specific for the Bedouin population were - maternal age over 35 years, recurrent pregnancy loss and in vitro fertilisation. However, sibling CHD was more common as a CHD risk factor in the Jewish compared with the Bedouin population (Adjusted OR 10.23 versus 3.19, respectively).Conclusions: The prevalence of CHD is higher in both the Bedouin and Jewish populations than previously reported. Several maternal factors were associated with CHD specifically for a certain population. Risk factors for CHD vary in populations residing in the same geographic area.
KW - Bedouin
KW - Congenital heart defects
KW - epidemiology
KW - maternal-foetal relations
UR - http://www.scopus.com/inward/record.url?scp=85068788582&partnerID=8YFLogxK
U2 - 10.1017/S1047951119001409
DO - 10.1017/S1047951119001409
M3 - Article
C2 - 31287039
AN - SCOPUS:85068788582
SN - 1047-9511
VL - 29
SP - 1040
EP - 1044
JO - Cardiology in the Young
JF - Cardiology in the Young
IS - 8
ER -