Risk factors for lymph nodes involvement in obese women with endometrial carcinomas

Michel Wissing, Cristina Mitric, Zainab Amajoud, Jeremie Abitbol, Amber Yasmeen, Vanessa López-Ozuna, Jeffrey How, Roy Kessous, Neta Eisenberg, Susie Lau, Shannon Salvador, Walter H. Gotlieb, Liron Kogan

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Objective: To assess risk factors for lymph node involvement in patients with endometrial cancer and a body-mass index (BMI) ≥30 kg/m2. Materials and methods: A retrospective analysis was performed of obese patients diagnosed with endometrial carcinoma between 2007 and 2015, treated in a single center in Montreal. Preoperative variables evaluated were age, BMI, parity, and preoperative ASA score, grade, CA-125 and histology. Odds ratios (OR) and hazard ratios (HR) and their respective 95% confidence intervals (95%CI) were calculated using multivariable logistic regression and Cox proportional hazard models. Results: The study included 230 women with BMI ≥30, 223 (97.0%) had complete staging. Pelvic lymph node involvement was detected in 26 patients (11.3%). Sentinel node detection and pelvic lymph node dissection decreased with increasing BMI (adjusted OR 0.86, 95%CI 0.76–0.97 and 0.76, 95%CI 0.59–0.96, respectively, per 1 kg/m2 increment). Pelvic lymph node involvement was inversely correlated with BMI (adjusted OR 0.88, 95%CI 0.79–0.99) and present in 16/85 (18.8%), 6/56 (10.7%), and 4/82 (4.9%) of patients with a BMI of 30.0–34.9, 35.0–39.9, and ≥40.0 kg/m2, respectively. Preoperative CA-125 was associated with lymph node involvement (adjusted OR 2.77, 95%CI 1.62–4.73, per quartile increment). Conclusion: Pelvic lymph node dissection might be omitted in selected cases of morbidly obese patients with failed sentinel nodes mapping and a low CA-125.

Original languageEnglish
Pages (from-to)27-33
Number of pages7
JournalGynecologic Oncology
Issue number1
StatePublished - 1 Oct 2019
Externally publishedYes


  • BMI
  • CA-125
  • Endometrial cancer
  • Lymph nodes invasion
  • Obesity

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology


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