Risk factors for periventricular echodensities and outcomes in preterm infants

Noga Kolnik, Tzipora Strauss, Omer Globus, Leah Leibovitch, Irit Schushan-Eisen, Iris Morag, Ayala Maayan-Metzger

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Objectives: To determine the incidence, risk factors and outcomes associated with transient and/or persistent periventricular echodensities (PVED) among preterm infants. Methods: Medical records of preterm infants born at ≤ 32 weeks gestational age (GA) with PVED and no other brain pathology were reviewed and compared to matched control infants in a case-controlled retrospective study. Neurodevelopmental outcomes at 8–24 months corrected age were documented. Results: A 17.8% incidence of PVED was recorded, with the highest incidence of 30–40% recorded at 29–31 weeks GA. Study and control groups were similar for all maternal parameters and neonatal morbidities, except for a higher incidence of respiratory distress syndrome among the study group. PVED at one month of age was predicted by 5 min Apgar score < 7 [OR = 33.78 (CI 2.94–388.06, p = 0.005)]. PVED was not associated with long-term neurodevelopmental disability. Conclusions: No risk factors or specific associated morbidities were identified among preterm infants with transient PVED. PVED at one month of age was predicted by low 5 min Apgar scores, possibly suggesting different pathogenesis or timing between the groups. Long-term outcome studies are needed to determine PVED impact.

Original languageEnglish
Pages (from-to)397-401
Number of pages5
JournalJournal of Maternal-Fetal and Neonatal Medicine
Issue number4
StatePublished - 16 Feb 2017
Externally publishedYes


  • Brain pathology
  • head ultrasound
  • risk factors

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


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