Risk factors for recurrent preterm delivery

Hanna Krymko, Asher Bashiri, Ana Smolin, Eyal Sheiner, Jury Bar-David, Ilana Shoham-Vardi, Hillel Vardi, Moshe Mazor

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Objective: To identify risk factors for recurrent preterm delivery among primiparous women with previous preterm delivery. Study design: A retrospective case-control study was designed: 152 primiparous women who delivered preterm (22-36 weeks) were divided into two groups: 81 had a second preterm delivery (study group) and 71 had a second-term delivery (control group). Exclusion criteria were induced preterm delivery, hydramnions and multiple gestations. Results: Comparing second preterm delivery before 34 weeks (n=36) to the second delivery of the control group, higher rates of hospitalization due to preterm labor were noted in the study versus the control group (52.8% versus 16.9%, P=0.001). The interval between pregnancies was shorter in the study subgroup, before 34 weeks gestational age, versus the controls (20.1±15.7 months versus 28.9±18.7 months, P=0.011). Multiple regression analyses, adjusted for confounding variables, found the occurrence of preterm labor and short interval between pregnancies, especially up to 12 months, as independent risk factors for the recurrence of preterm delivery (OR=4.98; P<0.001, OR=5.13; P=0.007, respectively). Conclusion: When adjusted for confounding variables, short interval between pregnancies is an independent risk factor for recurrent preterm delivery.

Original languageEnglish
Pages (from-to)160-163
Number of pages4
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Issue number2
StatePublished - 15 Apr 2004
Externally publishedYes


  • Preterm delivery
  • Preterm labor and interval between pregnancies
  • Recurrence
  • Risk factors

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology


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