RNAfbinv: An interactive Java application for fragment-based design of RNA sequences

Lina Weinbrand, Assaf Avihoo, Danny Barash

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Summary: In RNA design problems, it is plausible to assume that the user would be interested in preserving a particular RNA secondary structure motif, or fragment, for biological reasons. The preservation could be in structure or sequence, or both. Thus, the inverse RNA folding problem could benefit from considering fragment constraints. We have developed a new interactive Java application called RNA fragment-based inverse that allows users to insert an RNA secondary structure in dot-bracket notation. It then performs sequence design that conforms to the shape of the input secondary structure, the specified thermodynamic stability, the specified mutational robustness and the user-selected fragment after shape decomposition. In this shape-based design approach, specific RNA structural motifs with known biological functions are strictly enforced, while others can possess more flexibility in their structure in favor of preserving physical attributes and additional constraints.

Original languageEnglish
Pages (from-to)2938-2940
Number of pages3
JournalBioinformatics
Volume29
Issue number22
DOIs
StatePublished - 15 Nov 2013

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