Abstract
A systematic study of chiral adducts derived from amines as catalysts for aldol reaction revealed that enantioselective outcome depends on the chiral enamine intermediate and not the face-selective activation of aldehyde. A simple addition compound of proline and 8-hydroxy quinoline was found to be a good catalyst. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications® for the following free supplemental resource(s): Full experimental and spectral details.]
| Original language | English |
|---|---|
| Pages (from-to) | 352-360 |
| Number of pages | 9 |
| Journal | Synthetic Communications |
| Volume | 44 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1 Feb 2014 |
| Externally published | Yes |
Keywords
- Additives
- aldol reaction
- chiral amines
- organocatalyst
- pyrrolidine-catalyzed
ASJC Scopus subject areas
- Organic Chemistry