Role of additives in chiral amine-catalyzed direct aldol reaction

R. L. Sutar, N. N. Joshi

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


A systematic study of chiral adducts derived from amines as catalysts for aldol reaction revealed that enantioselective outcome depends on the chiral enamine intermediate and not the face-selective activation of aldehyde. A simple addition compound of proline and 8-hydroxy quinoline was found to be a good catalyst. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications® for the following free supplemental resource(s): Full experimental and spectral details.]

Original languageEnglish
Pages (from-to)352-360
Number of pages9
JournalSynthetic Communications
Issue number3
StatePublished - 1 Feb 2014
Externally publishedYes


  • Additives
  • aldol reaction
  • chiral amines
  • organocatalyst
  • pyrrolidine-catalyzed

ASJC Scopus subject areas

  • Organic Chemistry


Dive into the research topics of 'Role of additives in chiral amine-catalyzed direct aldol reaction'. Together they form a unique fingerprint.

Cite this