Role of blood-brain barrier injury in epileptogenesis

Alon Friedman; Uwe Heinemann

doi:10.1111/j.1528-1167.2010.02820.x

Role of blood-brain barrier injury in epileptogenesis

Alon Friedman, Uwe Heinemann

Physiology and Cell Biology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Epilepsy is common following various brain insults. We review experimental and clinical data supporting the involvement of a primary blood-brain barrier (BBB) injury in seizures and epileptogenesis. These data point to novel signaling cascades, which may offer new therapeutic targets for the prevention and treatment of epilepsy. For an expanded treatment of this topic see Jasper's Basic Mechanisms of the Epilepsies, Fourth Edition (Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, eds) published by Oxford University Press (available on the National Library of Medicine Bookshelf [NCBI] at).

Original language	English
Pages (from-to)	34
Number of pages	1
Journal	Epilepsia
Volume	51
Issue number	SUPPL. 5
DOIs	https://doi.org/10.1111/j.1528-1167.2010.02820.x
State	Published - 1 Dec 2010

Keywords

Astroglia
Cytokines
Epilepsy
Inflammation
Permeability
Seizures
Transforming growth factor beta
Vascular injury

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1111/j.1528-1167.2010.02820.x

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abstract = "Epilepsy is common following various brain insults. We review experimental and clinical data supporting the involvement of a primary blood-brain barrier (BBB) injury in seizures and epileptogenesis. These data point to novel signaling cascades, which may offer new therapeutic targets for the prevention and treatment of epilepsy. For an expanded treatment of this topic see Jasper's Basic Mechanisms of the Epilepsies, Fourth Edition (Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, eds) published by Oxford University Press (available on the National Library of Medicine Bookshelf [NCBI] at).",

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KW - Inflammation

KW - Permeability

KW - Seizures

KW - Transforming growth factor beta

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Role of blood-brain barrier injury in epileptogenesis

Abstract

Keywords

ASJC Scopus subject areas

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