Role of Deguelin in Chemoresistance

Sankar Jagadeeshan; M. Manu Prasad; Shivakumari Asha Nair

doi:10.1016/B978-0-12-812373-7.00014-0

Role of Deguelin in Chemoresistance

Sankar Jagadeeshan, M. Manu Prasad, Shivakumari Asha Nair

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

4 Scopus citations

Abstract

Natural agents are emerging as candidates with strong potential for targeted therapy against cancer as “nutraceuticals.” Deguelin, a rotenoid isolated from Mundulea sericea (Leguminosae) or Derris trifoliata, has been identified as a potent chemopreventive nutraceutical. Compendium of literature exhibiting its significant antitumorigenesis and antiproliferative activity in various types of cancer both in vitro and in vivo has recommended deguelin as a novel nutraceutical targeting tumorigenesis, apoptosis, cell-cycle arrest, and anti-angiogenesis for cancer chemoprevention and chemotherapy. In this chapter, we provide an overall insight on the role of deguelin as a chemosensitizer and its mechanism of action against cancer.

Original language	English
Title of host publication	Role of Nutraceuticals in Cancer Chemosensitization
Subtitle of host publication	Volume 2
Publisher	Elsevier
Pages	287-296
Number of pages	10
Volume	2
ISBN (Electronic)	9780128123737
ISBN (Print)	9780128123744
DOIs	https://doi.org/10.1016/B978-0-12-812373-7.00014-0
State	Published - 1 Jan 2017
Externally published	Yes

Keywords

Cancer
Chemoprevention
Deguelin
Mechanism
Nutraceuticals

ASJC Scopus subject areas

General Medicine
General Biochemistry, Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/B978-0-12-812373-7.00014-0

Cite this

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title = "Role of Deguelin in Chemoresistance",

abstract = "Natural agents are emerging as candidates with strong potential for targeted therapy against cancer as “nutraceuticals.” Deguelin, a rotenoid isolated from Mundulea sericea (Leguminosae) or Derris trifoliata, has been identified as a potent chemopreventive nutraceutical. Compendium of literature exhibiting its significant antitumorigenesis and antiproliferative activity in various types of cancer both in vitro and in vivo has recommended deguelin as a novel nutraceutical targeting tumorigenesis, apoptosis, cell-cycle arrest, and anti-angiogenesis for cancer chemoprevention and chemotherapy. In this chapter, we provide an overall insight on the role of deguelin as a chemosensitizer and its mechanism of action against cancer.",

keywords = "Cancer, Chemoprevention, Deguelin, Mechanism, Nutraceuticals",

author = "Sankar Jagadeeshan and Prasad, \{M. Manu\} and Nair, \{Shivakumari Asha\}",

year = "2017",

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doi = "10.1016/B978-0-12-812373-7.00014-0",

language = "English",

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booktitle = "Role of Nutraceuticals in Cancer Chemosensitization",

publisher = "Elsevier",

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TY - CHAP

T1 - Role of Deguelin in Chemoresistance

AU - Jagadeeshan, Sankar

AU - Prasad, M. Manu

AU - Nair, Shivakumari Asha

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Natural agents are emerging as candidates with strong potential for targeted therapy against cancer as “nutraceuticals.” Deguelin, a rotenoid isolated from Mundulea sericea (Leguminosae) or Derris trifoliata, has been identified as a potent chemopreventive nutraceutical. Compendium of literature exhibiting its significant antitumorigenesis and antiproliferative activity in various types of cancer both in vitro and in vivo has recommended deguelin as a novel nutraceutical targeting tumorigenesis, apoptosis, cell-cycle arrest, and anti-angiogenesis for cancer chemoprevention and chemotherapy. In this chapter, we provide an overall insight on the role of deguelin as a chemosensitizer and its mechanism of action against cancer.

AB - Natural agents are emerging as candidates with strong potential for targeted therapy against cancer as “nutraceuticals.” Deguelin, a rotenoid isolated from Mundulea sericea (Leguminosae) or Derris trifoliata, has been identified as a potent chemopreventive nutraceutical. Compendium of literature exhibiting its significant antitumorigenesis and antiproliferative activity in various types of cancer both in vitro and in vivo has recommended deguelin as a novel nutraceutical targeting tumorigenesis, apoptosis, cell-cycle arrest, and anti-angiogenesis for cancer chemoprevention and chemotherapy. In this chapter, we provide an overall insight on the role of deguelin as a chemosensitizer and its mechanism of action against cancer.

KW - Cancer

KW - Chemoprevention

KW - Deguelin

KW - Mechanism

KW - Nutraceuticals

UR - https://www.scopus.com/pages/publications/85139087342

U2 - 10.1016/B978-0-12-812373-7.00014-0

DO - 10.1016/B978-0-12-812373-7.00014-0

M3 - Chapter

AN - SCOPUS:85139087342

SN - 9780128123744

VL - 2

SP - 287

EP - 296

BT - Role of Nutraceuticals in Cancer Chemosensitization

PB - Elsevier

ER -

Role of Deguelin in Chemoresistance

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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