TY - GEN
T1 - Role of iL-1-mediated inflammation in tumor angiogenesis
AU - Voronov, Elena
AU - Carmi, Yaron
AU - Apte, Ron N.
PY - 2007/12/1
Y1 - 2007/12/1
N2 - Angiogenesis, or generation of new blood vessels from pre-existing vessels, is an integral part of many physiological or pathological processes, including tumor growth. Physiological angiogenesis is a complex process controlled by different proangiogenic as well as antiangiogenic factors. For angiogenic induction, the balance between these pro- and anti-angiogenic factors in the microenvironment has to shift in favor of proangiogenic factors, either by upregulation of these pro-angiogenic factors or by downregulation of angiogenic inhibitors. Proinflammatory cytokines, such as IL-1 and TNFα , were found to be major pro-angiogenic stimuli of both physiological and pathological angiogenesis. The IL-1 family consists of pleiotropic proinflammatory and immunoregulatory cytokines, namely, IL-1α and IL-1β , and one antagonistic protein, the IL-1 receptor antagonist (IL-1Ra), which binds to IL-1 receptors without transmitting an activation signal and represents a physiological inhibitor of preformed IL-1. Previously, we described an important role for microenvironment IL-1, mainly IL-1β , in tumor angiogenesis. In this chapter, we analyze the role of microenvironment host- and tumor cell-derived IL-1 on angiogenesis and the role of inflammation in pathological angiogenesis.
AB - Angiogenesis, or generation of new blood vessels from pre-existing vessels, is an integral part of many physiological or pathological processes, including tumor growth. Physiological angiogenesis is a complex process controlled by different proangiogenic as well as antiangiogenic factors. For angiogenic induction, the balance between these pro- and anti-angiogenic factors in the microenvironment has to shift in favor of proangiogenic factors, either by upregulation of these pro-angiogenic factors or by downregulation of angiogenic inhibitors. Proinflammatory cytokines, such as IL-1 and TNFα , were found to be major pro-angiogenic stimuli of both physiological and pathological angiogenesis. The IL-1 family consists of pleiotropic proinflammatory and immunoregulatory cytokines, namely, IL-1α and IL-1β , and one antagonistic protein, the IL-1 receptor antagonist (IL-1Ra), which binds to IL-1 receptors without transmitting an activation signal and represents a physiological inhibitor of preformed IL-1. Previously, we described an important role for microenvironment IL-1, mainly IL-1β , in tumor angiogenesis. In this chapter, we analyze the role of microenvironment host- and tumor cell-derived IL-1 on angiogenesis and the role of inflammation in pathological angiogenesis.
UR - http://www.scopus.com/inward/record.url?scp=34848903024&partnerID=8YFLogxK
U2 - 10.1007/978-0-387-72005-0_28
DO - 10.1007/978-0-387-72005-0_28
M3 - Conference contribution
C2 - 17713014
AN - SCOPUS:34848903024
SN - 9780387720043
T3 - Advances in Experimental Medicine and Biology
SP - 265
EP - 270
BT - Immune-Mediated Diseases
A2 - Shurin, Michael
A2 - Smolkin, Yuri
ER -
