Role of lycopene in preventing lipid peroxidation products, in commercial infant milk formula

Oshra Saphier, Tali Silberstein, Guy Yardeni, Jeanine Blumenfeld, Israel Zilbermann, Ariela Burg

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Abstract: Objectives: The aim of the study was to investigate whether lycopene from natural sources (tomato extract) is able to protect newborns milk formula, against oxidative damage caused by exposure to hydroxyl radicals, and is there a difference between milk substitutes from various sources. Methods: Four commercial brands of infant milk formula: two of the formulas were dairy milk (A-d and B-d) and two were based on soy bean vegan milk (A-s and B-s), were exposed to ionizing radiation radical (·OH). Lipid peroxidation was determined by measuring malondialdehyde (MDA) using thiobarbituric acid reactive substance test (TBARS). Results: When suspensions containing the four brands of formula were subjected to oxidizing media produced by ionizing radiation (hydroxyl radicals), lipid peroxidation increased linearly as a function of the irradiation dose (R = 0.99). It was found that lycopene in a concentration of 0.6 mM, reduced the radiation damage only in the soy-based formula; decrease of ∼40% of the damage achieved in B-s, and ∼20% reduction in the damage caused to A-s, significantly p < 0.01. Conclusions: Lycopene in dairy milk did not protect against hydroxyl radicals; however, lycopene found to protect against hydroxyl radicals in soy milk. This result suggests different mechanisms of radical production that arises from high iron levels present in the soy milk and involving the high-valent iron peroxo species.

Original languageEnglish
Pages (from-to)2865-2869
Number of pages5
JournalJournal of Maternal-Fetal and Neonatal Medicine
Issue number17
StatePublished - 1 Sep 2016


  • Dairy milk
  • ionizing radiation
  • vegan milk

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


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