Role of mineralocorticoids and glucocorticoids in blood pressure regulation in normotensive rats

Y. Yagil, R. Koreen, L. R. Krakoff

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22 Scopus citations


The separate role of mineralocorticoid and glucocorticoid hormone action in maintaining arterial pressure was studied in normotensive rats. Four groups were prepared: adrenalectomized (ADX) rats given 6 μg aldosterone/24 h (ALDO; n = 9) or 10 μg dexamethasone/24 h (DEX; n = 9) by intraperitoneal Alzet pumps, sham-operated controls (control; n = 10) and ADX rats with no hormone replacement (ADX; n = 9). All groups were given 1% NaCl + 2.5% glucose drinking solution. Measurements of plasma corticosterone and aldosterone and urinary aldosterone excretion confirmed the adequacy of the experimental groups. Forty-eight hours after ADX or sham, base-line intra-arterial mean arterial pressure (MAP) in conscious undisturbed rats was similar in the four groups. Captopril (1 mg/kg iv) produced a similar reduction in MAP in ALDO (-11 ± 2 mmHg) and DEX (-12 ± 1 mmHg) groups, despite a lower plasma renin activity (PRA) in ALDO (2.0 ± 0.7 and 6.0 ± 1.5 ng·ml-1·h-1, respectively; P < 0.05). dP(Me)TyrAVP (50 μg/kg/iv) caused a greater decrease in MAP in ALDO (-15 ± 3 mmHg) than in DEX (-8 ± 1 mmHg; P < 0.05). Combined blockade with both antagonists resulted in a greater MAP reduction in ALDO (-29 ± 4 mmHg) than in DEX (-15 ± 4 mmHg; P < 0.05). These results indicate that glucocorticoid hormone action maintains arterial pressure in ADX rats by mechanisms similar to normal rats and largely independent of the renin-angiotensin system and vasopressin. In contrast, mineralcorticoid replacement alone in ADX rats requires increased participation of both peptide systems for maintenance of arterial pressure.

Original languageEnglish
Pages (from-to)H1354-H1360
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Issue number6 (20/6)
StatePublished - 1 Jan 1986
Externally publishedYes

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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