Role of protease inhibition in myocardial preservation following ischemia and reperfusion

J. Gurevitch; Y. Paz; J. Barak; M. Matsa; A. Kramer; D. Pevni; E. Hochhauser; V. Yakirevich

Role of protease inhibition in myocardial preservation following ischemia and reperfusion

J. Gurevitch, Y. Paz, J. Barak, M. Matsa, A. Kramer, D. Pevni, E. Hochhauser, V. Yakirevich

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Aprotinin, a naturally occurring protease inhibitor, in concentrations of 10⁶ KIU/L was found to have no effect on myocardial performance in normally perfused isolated rat hearts, before ischemia. Given during the preischemic period, the drug had a significant protective effect on the reperfused hearts, following cardioplegic ischemia: better contractility upon reperfusion (p < 0.011), faster decline of the ischemic contracture, higher coronary flow (p < 0.025), lower AV-difference (p < 0.05), and lower CPK levels (p < 0.01).

Original language	English
Pages (from-to)	95-98
Number of pages	4
Journal	Journal of Cardiovascular Surgery
Volume	35
Issue number	SUPPL. 1-6
State	Published - 1 Dec 1994
Externally published	Yes

Keywords

Aprotinin
Ischemia
Myocardial reperfusion

ASJC Scopus subject areas

Surgery
Cardiology and Cardiovascular Medicine

Cite this

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title = "Role of protease inhibition in myocardial preservation following ischemia and reperfusion",

abstract = "Aprotinin, a naturally occurring protease inhibitor, in concentrations of 106 KIU/L was found to have no effect on myocardial performance in normally perfused isolated rat hearts, before ischemia. Given during the preischemic period, the drug had a significant protective effect on the reperfused hearts, following cardioplegic ischemia: better contractility upon reperfusion (p < 0.011), faster decline of the ischemic contracture, higher coronary flow (p < 0.025), lower AV-difference (p < 0.05), and lower CPK levels (p < 0.01).",

keywords = "Aprotinin, Ischemia, Myocardial reperfusion",

author = "J. Gurevitch and Y. Paz and J. Barak and M. Matsa and A. Kramer and D. Pevni and E. Hochhauser and V. Yakirevich",

year = "1994",

month = dec,

day = "1",

language = "English",

volume = "35",

pages = "95--98",

journal = "Journal of Cardiovascular Surgery",

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TY - JOUR

T1 - Role of protease inhibition in myocardial preservation following ischemia and reperfusion

AU - Gurevitch, J.

AU - Paz, Y.

AU - Barak, J.

AU - Matsa, M.

AU - Kramer, A.

AU - Pevni, D.

AU - Hochhauser, E.

AU - Yakirevich, V.

PY - 1994/12/1

Y1 - 1994/12/1

N2 - Aprotinin, a naturally occurring protease inhibitor, in concentrations of 106 KIU/L was found to have no effect on myocardial performance in normally perfused isolated rat hearts, before ischemia. Given during the preischemic period, the drug had a significant protective effect on the reperfused hearts, following cardioplegic ischemia: better contractility upon reperfusion (p < 0.011), faster decline of the ischemic contracture, higher coronary flow (p < 0.025), lower AV-difference (p < 0.05), and lower CPK levels (p < 0.01).

AB - Aprotinin, a naturally occurring protease inhibitor, in concentrations of 106 KIU/L was found to have no effect on myocardial performance in normally perfused isolated rat hearts, before ischemia. Given during the preischemic period, the drug had a significant protective effect on the reperfused hearts, following cardioplegic ischemia: better contractility upon reperfusion (p < 0.011), faster decline of the ischemic contracture, higher coronary flow (p < 0.025), lower AV-difference (p < 0.05), and lower CPK levels (p < 0.01).

KW - Aprotinin

KW - Ischemia

KW - Myocardial reperfusion

UR - http://www.scopus.com/inward/record.url?scp=0028672561&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0028672561

SN - 0021-9509

VL - 35

SP - 95

EP - 98

JO - Journal of Cardiovascular Surgery

JF - Journal of Cardiovascular Surgery

IS - SUPPL. 1-6

ER -

Role of protease inhibition in myocardial preservation following ischemia and reperfusion

Abstract

Keywords

ASJC Scopus subject areas

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