Room temperature, copper-catalyzed amination of bromonaphthyridines with aqueous ammonia

Cyrus A. Anderson, Phillip G. Taylor, Mary A. Zeller, Steven C. Zimmerman

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

(Figure Presented) Room temperature, copper-catalyzed amination of amido-bromo-1,8-naphthyridines is reported. Use of Cu2O and aqueous ammonia at ambient temperature affords amination products in 10-87% yield. Bromonaphthyridines are prepared in 15-65% yield via treatment of amidonaphthyridinones with phosphorus tribromide. This methodology provides an alternative route to functional, nonsymmetric 2,7-diamido-1,8-naphthyridines.

Original languageEnglish
Pages (from-to)4848-4851
Number of pages4
JournalJournal of Organic Chemistry
Volume75
Issue number14
DOIs
StatePublished - 16 Jul 2010
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry

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