Abstract
(Figure Presented) Room temperature, copper-catalyzed amination of amido-bromo-1,8-naphthyridines is reported. Use of Cu2O and aqueous ammonia at ambient temperature affords amination products in 10-87% yield. Bromonaphthyridines are prepared in 15-65% yield via treatment of amidonaphthyridinones with phosphorus tribromide. This methodology provides an alternative route to functional, nonsymmetric 2,7-diamido-1,8-naphthyridines.
Original language | English |
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Pages (from-to) | 4848-4851 |
Number of pages | 4 |
Journal | Journal of Organic Chemistry |
Volume | 75 |
Issue number | 14 |
DOIs | |
State | Published - 16 Jul 2010 |
Externally published | Yes |
ASJC Scopus subject areas
- Organic Chemistry