@article{98639f8f5aa045a6af30d81b36993b7c,
title = "Route to Benzimidazol-2-ones via Decarbonylative Ring Contraction of Quinoxalinediones: Application to the synthesis of flibanserin, a drug for treating hypoactive sexual desire disorder in women and marine natural product hunanamycin analogue",
abstract = "A simple and practical method to access a variety of benzimidazol-2-ones is reported here. A series of N-alkyl-substituted benzimidazol-2-ones were synthesized by decarbonylative ring contraction starting from corresponding quinoxalinediones for the first time. The utility of the method has been demonstrated by synthesizing recently approved controversial drug flibanserin (Addyi) and a urea analogue of marine antibiotic natural product hunanamycin-A.",
author = "Shingare, {Rahul D.} and Kulkarni, {Akshay S.} and Sutar, {Revannath L.} and {Srinivasa Reddy}, D.",
note = "Funding Information: We thank the CSIR (ORIGIN: CSC0108 and NICE-P: CSC0109 programs under XII Five Year Plan) for the financial support. R.D.S. thanks UGC for the award of a research fellowship. Publisher Copyright: {\textcopyright} 2017 American Chemical Society.",
year = "2017",
month = aug,
day = "31",
doi = "10.1021/acsomega.7b00819",
language = "English",
volume = "2",
pages = "5137--5141",
journal = "ACS Omega",
issn = "2470-1343",
publisher = "American Chemical Society",
number = "8",
}