Roux-en-Y gastric bypass vs sleeve gastrectomy for obese patients with type 2 diabetes: A randomised trial

Andrei Keidar, Karen J. Hershkop, Limor Marko, Chaya Schweiger, Lior Hecht, Noam Bartov, Assaf Kedar, Ram Weiss

Research output: Contribution to journalArticlepeer-review

106 Scopus citations


Aims/hypothesis: Bariatric surgery is gaining acceptance as a 'metabolic surgical intervention' for patients with type 2 diabetes. The optimal form of surgery and the mechanism of action of these procedures are much debated. We compared two bariatric procedures for obese patients with type 2 diabetes and evaluated their effects on HbA1c and glucose tolerance. Methods: We performed a parallel un-blinded randomised trial of Roux-en-Y gastric bypass (RYGB) vs sleeve gastrectomy (SG) in 41 obese patients with type 2 diabetes, who were bariatric surgery candidates attending the obesity clinic. HbA 1c, body composition and glucose tolerance were evaluated at baseline, and at 3 and 12 months. Results: Of the 41 patients, 37 completed the follow-up (19 RYGB, 18 SG). Both groups had similar baseline anthropometric and biochemical measures, and showed comparable weight loss and fat:fat-free mass ratio changes at 12 months. A similar normalisation of HbA1c levels was observed as early as 3 months post-surgery (6.37 ± 0.71% vs 6.23 ± 0.69% for RYGB vs SG respectively, p < 0.001 in both groups for baseline vs follow-up). Conclusions/interpretation: In this study, RYGB did not have a superior effect in comparison to SG with regard to HbA1c levels or weight loss during 12 months of follow-up. Trial registration: NCT00667706 Funding: This work was supported by grant no. 3-000-8480 from the Israel Ministry of Health Chief Scientist, the Stephen Morse Diabetes Research Foundation and by Johnson & Johnson.

Original languageEnglish
Pages (from-to)1914-1918
Number of pages5
Issue number9
StatePublished - 1 Sep 2013
Externally publishedYes


  • Bariatric surgery
  • Roux-en-Y gastric bypass
  • Sleeve gastrectomy
  • Type 2 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism


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