[R,S]-ethambutol dihydrochloride: Variable-temperature studies of a dimorphic system with very similar packing

Janice M. Rubin-Preminger, Joel Bernstein, Robin K. Harris, Ivana Radosavljevic Evans, Phuong Y. Ghi

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

The two polymorphs (Forms I and II) of [R,S]-ethambutol dihydrochloride transform enantiotropically and reversibly in a single-crystal-to-single-crystal phase transformation mode. These structurally very similar forms have been characterized and their thermodynamic relationship has been investigated by variable-temperature solid-state carbon-13 nuclear magnetic resonance, variable-temperature powder X-ray diffraction, differential scanning calorimetry, and optical microscopy. The nuclear magnetic resonance results are compared with those for the two polymorphs of the [S,S] diastereomer with known structures.

Original languageEnglish
Pages (from-to)2810-2819
Number of pages10
JournalJournal of Pharmaceutical Sciences
Volume93
Issue number11
DOIs
StatePublished - 1 Jan 2004

Keywords

  • Diastereomer
  • Enantiotropic
  • Magic angle 13C NMR
  • Phase transition
  • Polymorphism

ASJC Scopus subject areas

  • Pharmaceutical Science

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