Ruthenium-catalyzed cyclization of anilides with substituted propiolates or acrylates: An efficient route to 2-quinolinones

Rajendran Manikandan, Masilamani Jeganmohan

Research output: Contribution to journalArticlepeer-review

81 Scopus citations

Abstract

A Ru-catalyzed cyclization of anilides with propiolates or acrylates affording 2-quinolinones having diverse functional groups in good to excellent yields is described. Later, 2-quinolinones were converted into 3-halo-2-quinolinones and 2-chloroquinolines. The proposed mechanism was strongly supported by experimental evidence and deuterium labeling studies.

Original languageEnglish
Pages (from-to)3568-3571
Number of pages4
JournalOrganic Letters
Volume16
Issue number13
DOIs
StatePublished - 3 Jul 2014
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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