S100B in maternal circulation of pregnancies complicated by FGR and brain sparing

Shani S. Swissa, Joel Baron, Dan Tirosh, Shimrit Yaniv-Salem, Ilan Shelef, Reli Hershkovitz, Ofer Beharier

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Objective: To determine whether the presence of brain sparing in fetal growth restricted (FGR) fetuses involves elevation of the cerebral injury biomarker S100B in maternal circulation. Methods: We included 63 women with suspected small for gestational age (SGA) fetuses between 24 and 35 +6/7 weeks of gestation. Maternal plasma angiogenic factors measurements and sonographic evaluation were performed at recruitment. Next, we subdivided our SGA cohort into three groups: SGA fetuses, FGR fetuses without brain-sparing, and FGR fetuses with brain-sparing (FGR-BS). Serum S100B concentration was calculated as S100B µg/L, S100B MoM, and the ratio S100B/ estimated fetal weight (EFW). We also report one case of S100B concentration surge in maternal serum following the diagnosis of fetal intraventricular hemorrhage (IVH). Results: The FGR-BS group had higher maternal S100B µg/L (p < 0.01, p < 0.05, respectively), S100B MoM (p < 0.001, p < 0.001, respectively), and S100B/EFW (p < 0.001, p < 0.01, respectively), compared to the SGA and FGR groups. In the case report, maternal serum S100B concentrations were 0.0346 µg/L before, and 0.0874 µg/L after IVH occurrence. Conclusions: S100B concentration in maternal serum increased in pregnancies complicated by FGR and brain sparing. These results may substantiate in-utero cerebral injury and may explain the adverse neurocognitive outcomes reported for this group.

Original languageEnglish
Pages (from-to)141-150
Number of pages10
JournalPrenatal Diagnosis
Issue number1
StatePublished - 1 Jan 2022

ASJC Scopus subject areas

  • Genetics(clinical)
  • Obstetrics and Gynecology


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