Safety and immunogenicity of Shigella sonnei and Shigella flexneri 2a O- specific polysaccharide conjugates in children

Shai Ashkenazi, Justen H. Passwell, Efrat Harlev, Dan Miron, Ron Dagan, Nahid Farzan, Reut Ramon, Fathy Majadly, Dolores A. Bryla, Arthur B. Karpas, John B. Robbins, Rachel Schneerson

Research output: Contribution to journalArticlepeer-review

69 Scopus citations

Abstract

O-specific polysaccharide conjugates of shigellae were safe and immunogenic in young adults, and a Shigella sonnei conjugate conferred protection [1-3]. Shigellosis is primarily a disease of children; therefore, the safety and immunogenicity of S. sonnei and Shigella flexneri 2a conjugates were studied in 4- to 7-year-old children. Local and systemic reactions were minimal. The first injection of both conjugates elicited significant rises in geometric mean levels of serum IgG only to the homologous lipopolysaccharide (LPS) (S. sonnei, 0.32-8.25 ELISA units [EU]; S. flexneri 2a, 1.15-20.5 EU; P < .0001). Revaccination at 6 weeks induced a booster response to S. flexneri 2a LPS (20.5-30.5 EU, P = .003). Six months later, the geometric mean levels of IgG anti-LPS for both groups were higher than the prevaccination levels (P < .0001). Similar, but lesser, rises were observed for IgM and IgA anti-LPS. The investigational Shigella conjugates were safe and immunogenic in children and merit evaluation of their efficacy.

Original languageEnglish
Pages (from-to)1565-1568
Number of pages4
JournalJournal of Infectious Diseases
Volume179
Issue number6
DOIs
StatePublished - 7 Jun 1999

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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