Safety of labor induction with prostaglandin E2 in grandmultiparous women

Jigal Haas, Eran Barzilay, Benny Chayen, Oshrit Lebovitz, Yoav Yinon, Israel Hendler, Linda Harel

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Objective: The aim of this study was to assess the safety of labor induction with vaginal prostaglandin E2 (PGE2) in grandmultiparous women. Methods: We conducted a retrospective cohort study of 1376 grandmultiparous women who underwent induction of labor with low dose PGE2. The primary outcome was uterine rupture and secondary outcomes included mode of delivery, postpartum hemorrhage and five minutes Apgar score. Results: One case was diagnosed with uterine rupture (0.07%). Vaginal delivery was achieved in 1329 (96.6%) patients, whereas 47 (3.4%) patients had emergent cesarean delivery. Five minutes Apgar score ≤7 was recorded in three cases (0.2%). There was no correlation between parity and cesarean delivery rate or low Apgar score. There were no significant differences between the grandmultiparous and great-grandmultiparous patients regarding cesarean delivery rate (3.1 vs. 5%, P = 0.12), operative vaginal delivery rate (2 vs. 2.3%, P = 0.74) or postpartum hemorrhage rate (0.8 vs. 1.1%, P = 0.6). Conclusions: Low dose PGE2 is a safe and efficient method for induction of labor in grandmultiparous and great-grandmultiparous women.

Original languageEnglish
Pages (from-to)49-51
Number of pages3
JournalJournal of Maternal-Fetal and Neonatal Medicine
Issue number1
StatePublished - 1 Jan 2013
Externally publishedYes


  • Grandmultiparity
  • Induction of labor
  • Prostaglandin E2
  • Uterine rupture

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


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