TY - JOUR
T1 - Sarcopenia is associated with a greater incidence of delayed gastric emptying following pancreaticoduodenectomy
AU - Tankel, James
AU - Dagan, Amir
AU - Vainberg, Elena
AU - Boaz, Elad
AU - Mogilevsky, Liel
AU - Hadas, Irit
AU - Reissman, Petachia
AU - Ben Haim, Menahem
N1 - Publisher Copyright:
© 2018 European Society for Clinical Nutrition and Metabolism
PY - 2018/10/1
Y1 - 2018/10/1
N2 - Background and aims: Sarcopenia is the degenerative loss of skeletal muscle and has been associated with a variety of post-operative complications. We propose sarcopenia is associated with delayed gastric emptying (DGE) following elective pancreaticoduodenectomy (PD). Methods: A retrospective analysis of a computerised database maintained in real time of all patients undergoing PD within our hepatobiliary unit was performed. The cross-sectional area of the psoas muscle at the upper border of L3 was calculated and corrected for patient height. The lowest quartile of gender specific groups was considered to be sarcopenic. Results: 61 patients were included, 32 male and 29 female of whom 8 from each group were sarcopenic (26.2%). Although the sarcopenic and non-sarcopenia groups were found to be comparable, significantly more sarcopenic patients were older (75 vs 64 years, p = 0.003), had a lower body mass index (21.9 vs 25.0 kg/m2, p = 0.003) and suffered from DGE (7/16 vs 8/45, p = 0.045). On multivariate analysis, these variables maintained their significance with DGE having an OR of 6.042 (p = 0.036). Conclusion: Sarcopenia is significantly associated with DGE, older age and lower BMI in this specific cohort of patients. Further research into the reversibility of this phenomenon is warranted.
AB - Background and aims: Sarcopenia is the degenerative loss of skeletal muscle and has been associated with a variety of post-operative complications. We propose sarcopenia is associated with delayed gastric emptying (DGE) following elective pancreaticoduodenectomy (PD). Methods: A retrospective analysis of a computerised database maintained in real time of all patients undergoing PD within our hepatobiliary unit was performed. The cross-sectional area of the psoas muscle at the upper border of L3 was calculated and corrected for patient height. The lowest quartile of gender specific groups was considered to be sarcopenic. Results: 61 patients were included, 32 male and 29 female of whom 8 from each group were sarcopenic (26.2%). Although the sarcopenic and non-sarcopenia groups were found to be comparable, significantly more sarcopenic patients were older (75 vs 64 years, p = 0.003), had a lower body mass index (21.9 vs 25.0 kg/m2, p = 0.003) and suffered from DGE (7/16 vs 8/45, p = 0.045). On multivariate analysis, these variables maintained their significance with DGE having an OR of 6.042 (p = 0.036). Conclusion: Sarcopenia is significantly associated with DGE, older age and lower BMI in this specific cohort of patients. Further research into the reversibility of this phenomenon is warranted.
KW - Complication
KW - Delayed gastric emptying
KW - Pancreaticoduodenectomy
UR - http://www.scopus.com/inward/record.url?scp=85048938359&partnerID=8YFLogxK
U2 - 10.1016/j.clnesp.2018.05.011
DO - 10.1016/j.clnesp.2018.05.011
M3 - Article
C2 - 30144881
AN - SCOPUS:85048938359
SN - 2405-4577
VL - 27
SP - 105
EP - 109
JO - Clinical Nutrition ESPEN
JF - Clinical Nutrition ESPEN
ER -