TY - JOUR
T1 - Scaling physiologic function from cell to tissue in asthma, cancer, and development
AU - Sharma, Yasha
AU - Atia, Lior
AU - Rhodes, Christalyn Sims
AU - DeCamp, Stephen J.
AU - Mitchel, Jennifer
AU - Fredberg, Jeffrey J.
N1 - Publisher Copyright:
Copyright © 2018 by the American Thoracic Society.
PY - 2018/2/1
Y1 - 2018/2/1
N2 - The formation of an integrated tissue from individual cells depends on the properties of the individual cells as well as the interaction of many cells acting as a collective. Three fundamental physiological processes govern the collective scaling from the individual cell to a working tissue: cell sorting, tissue assembly, and collective cellular migration. Mechanistically, cell sorting is governed by differential adhesion, whereas tissue assembly is controlled by the epithelial-tomesenchymal transition and its inverse, the mesenchymal-toepithelial transition. The mechanism driving collective cellular migration, however, is not clear. To fill that gap, here we consider cell jamming and unjamming, and their role in collective cellular migration.
AB - The formation of an integrated tissue from individual cells depends on the properties of the individual cells as well as the interaction of many cells acting as a collective. Three fundamental physiological processes govern the collective scaling from the individual cell to a working tissue: cell sorting, tissue assembly, and collective cellular migration. Mechanistically, cell sorting is governed by differential adhesion, whereas tissue assembly is controlled by the epithelial-tomesenchymal transition and its inverse, the mesenchymal-toepithelial transition. The mechanism driving collective cellular migration, however, is not clear. To fill that gap, here we consider cell jamming and unjamming, and their role in collective cellular migration.
KW - Collective
KW - Epithelium
KW - Jamming
KW - Migration
UR - http://www.scopus.com/inward/record.url?scp=85045335309&partnerID=8YFLogxK
U2 - 10.1513/AnnalsATS.201710-790KV
DO - 10.1513/AnnalsATS.201710-790KV
M3 - Article
AN - SCOPUS:85045335309
SN - 2325-6621
VL - 15
SP - S35-S37
JO - Annals of the American Thoracic Society
JF - Annals of the American Thoracic Society
ER -