Scavenging neurotoxic aldehydes using lysine carbon dots

Daniel Nir Bloch, Michele Sandre, Shani Ben Zichri, Anna Masato, Sofiya Kolusheva, Luigi Bubacco, Raz Jelinek

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Reactive aldehydes generated in cells and tissues are associated with adverse physiological effects. Dihydroxyphenylacetaldehyde (DOPAL), the biogenic aldehyde enzymatically produced from dopamine, is cytotoxic, generates reactive oxygen species, and triggers aggregation of proteins such as α-synuclein implicated in Parkinson's disease. Here, we demonstrate that carbon dots (C-dots) prepared from lysine as the carbonaceous precursor bind DOPAL molecules through interactions between the aldehyde units and amine residues on the C-dot surface. A set of biophysical and in vitro experiments attests to attenuation of the adverse biological activity of DOPAL. In particular, we show that the lysine-C-dots inhibit DOPAL-induced α-synuclein oligomerization and cytotoxicity. This work underlines the potential of lysine-C-dots as an effective therapeutic vehicle for aldehyde scavenging.

Original languageEnglish
Pages (from-to)1356-1367
Number of pages12
JournalNanoscale Advances
Volume5
Issue number5
DOIs
StatePublished - 19 Jan 2023

ASJC Scopus subject areas

  • General Engineering
  • Bioengineering
  • Atomic and Molecular Physics, and Optics
  • General Chemistry
  • General Materials Science

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