Schizophrenia, chronic hospitalization and the 5-HT(2C) receptor gene

R. H. Segman; R. P. Ebstein; U. Heresco-Levy; M. Gorfine; M. Avnon; E. Gur; L. Nemanov; B. Lerer

doi:10.1097/00041444-199722000-00003

Schizophrenia, chronic hospitalization and the 5-HT(2C) receptor gene

R. H. Segman, R. P. Ebstein, U. Heresco-Levy, M. Gorfine, M. Avnon, E. Gur, L. Nemanov, B. Lerer

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Frequency of a polymorphism in the coding region of the 5-hydroxytryptamine(2C) (5-HT(2C)) receptor gene (HTR2C Xq24) was not significantly different in 122 unrelated Israeli schizophrenia patients compared with 180 control subjects matched for gender and ethnicity. However, proportion of time spent in hospital since the first admission was significantly greater in patients hemi- or homozygous for the 5-HT(2Cser) allele than in patients carrying other genotypes (p = 0.006). The 5-HT(2Cser) genotype conferred a 3.3-fold increased risk for lifetime hospitalization exceeding 10 years. Genetically determined variation in the 5-HT(2C) receptor may influence the clinical course and phenotypic expression of schizophrenia.

Original language	English
Pages (from-to)	75-78
Number of pages	4
Journal	Psychiatric Genetics
Volume	7
Issue number	2
DOIs	https://doi.org/10.1097/00041444-199722000-00003
State	Published - 1 Jan 1997
Externally published	Yes

Keywords

5-HT(2c) receptor polymorphism
Chronic hospitalization
Genetic association
Schizophrenia
Serotonin

ASJC Scopus subject areas

Genetics
Genetics(clinical)
Psychiatry and Mental health
Biological Psychiatry

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10.1097/00041444-199722000-00003

Cite this

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title = "Schizophrenia, chronic hospitalization and the 5-HT(2C) receptor gene",

abstract = "Frequency of a polymorphism in the coding region of the 5-hydroxytryptamine(2C) (5-HT(2C)) receptor gene (HTR2C Xq24) was not significantly different in 122 unrelated Israeli schizophrenia patients compared with 180 control subjects matched for gender and ethnicity. However, proportion of time spent in hospital since the first admission was significantly greater in patients hemi- or homozygous for the 5-HT(2Cser) allele than in patients carrying other genotypes (p = 0.006). The 5-HT(2Cser) genotype conferred a 3.3-fold increased risk for lifetime hospitalization exceeding 10 years. Genetically determined variation in the 5-HT(2C) receptor may influence the clinical course and phenotypic expression of schizophrenia.",

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AU - Segman, R. H.

AU - Ebstein, R. P.

AU - Heresco-Levy, U.

AU - Gorfine, M.

AU - Avnon, M.

AU - Gur, E.

AU - Nemanov, L.

AU - Lerer, B.

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N2 - Frequency of a polymorphism in the coding region of the 5-hydroxytryptamine(2C) (5-HT(2C)) receptor gene (HTR2C Xq24) was not significantly different in 122 unrelated Israeli schizophrenia patients compared with 180 control subjects matched for gender and ethnicity. However, proportion of time spent in hospital since the first admission was significantly greater in patients hemi- or homozygous for the 5-HT(2Cser) allele than in patients carrying other genotypes (p = 0.006). The 5-HT(2Cser) genotype conferred a 3.3-fold increased risk for lifetime hospitalization exceeding 10 years. Genetically determined variation in the 5-HT(2C) receptor may influence the clinical course and phenotypic expression of schizophrenia.

AB - Frequency of a polymorphism in the coding region of the 5-hydroxytryptamine(2C) (5-HT(2C)) receptor gene (HTR2C Xq24) was not significantly different in 122 unrelated Israeli schizophrenia patients compared with 180 control subjects matched for gender and ethnicity. However, proportion of time spent in hospital since the first admission was significantly greater in patients hemi- or homozygous for the 5-HT(2Cser) allele than in patients carrying other genotypes (p = 0.006). The 5-HT(2Cser) genotype conferred a 3.3-fold increased risk for lifetime hospitalization exceeding 10 years. Genetically determined variation in the 5-HT(2C) receptor may influence the clinical course and phenotypic expression of schizophrenia.

KW - 5-HT(2c) receptor polymorphism

KW - Chronic hospitalization

KW - Genetic association

KW - Schizophrenia

KW - Serotonin

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Schizophrenia, chronic hospitalization and the 5-HT(2C) receptor gene

Abstract

Keywords

ASJC Scopus subject areas

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