Screening for Brain Involvement in Infants with Multifocal Cutaneous Infantile Hemangiomas

Rivka Friedland, Dan Ben Amitai, Alex Zvulunov

    Research output: Contribution to journalArticlepeer-review

    4 Scopus citations


    Background: Multifocal (≥5) infantile hemangiomas (IHs) are known as a risk factor for extracutaneous involvement. Liver is the most commonly involved organ, but involvement of other systems has also been reported. This study aims to describe the characteristic findings in a group of infants with multiple cutaneous hemangiomas, with emphasis on intracranial involvement. Methods: A retrospective case series study was carried out in a pediatric dermatology unit of a tertiary pediatric medical center. Patients diagnosed with multiple cutaneous IHs from 2006 to 2015 were identified by a computerized search. Clinical data were retrieved from the medical charts. Results: A total of 60 infants (37 females and 23 males) were identified for analysis. Forty-four brain ultrasounds were recorded and reported as normal. One patient out of the 44 was later diagnosed with a small asymptomatic hemangioma seen on a brain MRI/MRA done for another indication. Conclusion: Brain hemangiomas may present as an asymptomatic incidental finding in infants presenting with multifocal cutaneous and liver IHs. The single case reported in our study emphasizes the low prevalence and the benign course expected. Therefore, routine ultrasound screening for brain involvement is probably unnecessary for this population.

    Original languageEnglish
    Pages (from-to)435-440
    Number of pages6
    Issue number6
    StatePublished - 1 Apr 2018


    • Infantile hemangioma
    • Noninvasive imaging
    • Vascular tumor


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