Sebaceous adenocarcinoma of meibomian gland origin with targetoid intra‐nuclear inclusion

Jed Goldstein, Ilana Avinoah, Tova Lifshitz

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Neoplastic proliferation of the meibomian glands is most often characterized by a tarsal tumor of the eyelid conjunctiva, having the clinical appearance of a chalazion. As such, the tumor is frequently not recognized as a neoplasm and is treated conservatively as an inflammatory lesion. A protracted clinical course combined with repeated surgical excisions typify this slow‐growing tumor of sebaceous gland cells. In addition to the usual features of polygonal cell shape, abundant cytoplasm, and numerous fat vacuoles, we describe the presence of a peculiar nuclear inclusion seen only in the parenchymal cells of this tumor, and having the appearance of concentric layers of electron‐dense material surrounding an opaque electron lucent core.

Original languageEnglish
Pages (from-to)124-128
Number of pages5
JournalJournal of Surgical Oncology
Issue number2
StatePublished - 1 Jan 1987
Externally publishedYes


  • adenocarcinoma
  • conjunctiva
  • eyelid tumor
  • meibomian glands
  • nuclear inclusion
  • sebaceous glands
  • targetoid inclusions

ASJC Scopus subject areas

  • Surgery
  • Oncology


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