Seborrhea-like dermatitis with psoriasiform elements caused by a mutation in ZNF750, encoding a putative C2H2 zinc finger protein

Ramon Y. Birnbaum; Alex Zvulunov; Dafna Hallel-Halevy; Emanuella Cagnano; Gal Finer; Rivka Ofir; Dan Geiger; Eldad Silberstein; Yael Feferman; Ohad S. Birk

doi:10.1038/ng1813

Seborrhea-like dermatitis with psoriasiform elements caused by a mutation in ZNF750, encoding a putative C2H2 zinc finger protein

Ramon Y. Birnbaum, Alex Zvulunov, Dafna Hallel-Halevy, Emanuella Cagnano, Gal Finer, Rivka Ofir, Dan Geiger, Eldad Silberstein, Yael Feferman, Ohad S. Birk

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

We describe an Israeli Jewish Moroccan family presenting with autosomal dominant seborrhea-like dermatosis with psoriasiform elements, including enhanced keratinocyte proliferation, parakeratosis, follicular plugging, Pityrosporum ovale overgrowth and dermal CD4 lymphocyte infiltrate. We mapped the disease gene to a 0.5-cM region overlapping the PSORS2 locus (17q25) and identified a frameshift mutation in ZNF750, which encodes a putative C2H2 zinc finger protein. ZNF750 is normally expressed in keratinocytes but not in fibroblasts and is barely detectable in CD4 lymphocytes.

Original language	English
Pages (from-to)	749-751
Number of pages	3
Journal	Nature Genetics
Volume	38
Issue number	7
DOIs	https://doi.org/10.1038/ng1813
State	Published - 1 Jul 2006

ASJC Scopus subject areas

Genetics

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title = "Seborrhea-like dermatitis with psoriasiform elements caused by a mutation in ZNF750, encoding a putative C2H2 zinc finger protein",

abstract = "We describe an Israeli Jewish Moroccan family presenting with autosomal dominant seborrhea-like dermatosis with psoriasiform elements, including enhanced keratinocyte proliferation, parakeratosis, follicular plugging, Pityrosporum ovale overgrowth and dermal CD4 lymphocyte infiltrate. We mapped the disease gene to a 0.5-cM region overlapping the PSORS2 locus (17q25) and identified a frameshift mutation in ZNF750, which encodes a putative C2H2 zinc finger protein. ZNF750 is normally expressed in keratinocytes but not in fibroblasts and is barely detectable in CD4 lymphocytes.",

author = "Birnbaum, {Ramon Y.} and Alex Zvulunov and Dafna Hallel-Halevy and Emanuella Cagnano and Gal Finer and Rivka Ofir and Dan Geiger and Eldad Silberstein and Yael Feferman and Birk, {Ohad S.}",

note = "Funding Information: We deeply thank the Morris Kahn Foundation for Humanitarian Support for making this research possible.",

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T1 - Seborrhea-like dermatitis with psoriasiform elements caused by a mutation in ZNF750, encoding a putative C2H2 zinc finger protein

AU - Birnbaum, Ramon Y.

AU - Zvulunov, Alex

AU - Hallel-Halevy, Dafna

AU - Cagnano, Emanuella

AU - Finer, Gal

AU - Ofir, Rivka

AU - Geiger, Dan

AU - Silberstein, Eldad

AU - Feferman, Yael

AU - Birk, Ohad S.

N1 - Funding Information: We deeply thank the Morris Kahn Foundation for Humanitarian Support for making this research possible.

PY - 2006/7/1

Y1 - 2006/7/1

N2 - We describe an Israeli Jewish Moroccan family presenting with autosomal dominant seborrhea-like dermatosis with psoriasiform elements, including enhanced keratinocyte proliferation, parakeratosis, follicular plugging, Pityrosporum ovale overgrowth and dermal CD4 lymphocyte infiltrate. We mapped the disease gene to a 0.5-cM region overlapping the PSORS2 locus (17q25) and identified a frameshift mutation in ZNF750, which encodes a putative C2H2 zinc finger protein. ZNF750 is normally expressed in keratinocytes but not in fibroblasts and is barely detectable in CD4 lymphocytes.

AB - We describe an Israeli Jewish Moroccan family presenting with autosomal dominant seborrhea-like dermatosis with psoriasiform elements, including enhanced keratinocyte proliferation, parakeratosis, follicular plugging, Pityrosporum ovale overgrowth and dermal CD4 lymphocyte infiltrate. We mapped the disease gene to a 0.5-cM region overlapping the PSORS2 locus (17q25) and identified a frameshift mutation in ZNF750, which encodes a putative C2H2 zinc finger protein. ZNF750 is normally expressed in keratinocytes but not in fibroblasts and is barely detectable in CD4 lymphocytes.

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Seborrhea-like dermatitis with psoriasiform elements caused by a mutation in ZNF750, encoding a putative C2H2 zinc finger protein

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