TY - JOUR
T1 - Secondary metabolites of aeromonas veronii strain A134 isolated from a Microcystis aeruginosa Bloom
AU - Weiss, Gad
AU - Kovalerchick, Dimitry
AU - Murik, Omer
AU - Sukenik, Assaf
AU - Kaplan, Aaron
AU - Carmeli, Shmuel
N1 - Funding Information:
Funding: This research was funded by the Israeli Ministry of Science and Technology and by the Israel Science Foundation Grant 1298/13. Gad Weiss was supported by Blue-Green Water Technologies Ltd. and the Yohai Ben-Nun memorial fund.
Publisher Copyright:
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2019/6/1
Y1 - 2019/6/1
N2 - Aeromonas veronii strain A134 was isolated from Microcystis aeruginosa colonies collected from Lake Kinneret (Sea of Galilee), Israel. The Aeromonas culture media inhibited the growth of M. aeruginosa (strain MGK). The crude extract of a large-scale culture of A. veronii A134 was separated in a few chromatographic steps to yield three new secondary metabolites, 9-chlorolumichrome (1), veronimide (2) and veronipyrazine (3), along with a known lumichrome and several known diketopiperazines. The structures of the new compounds were established by analyses of the data from 1D and 2D NMR experiments and HRMS data of the compounds, as well as a single-crystal X-ray analysis of synthetic 1. The structure elucidation and proposed biogenesis of the new compounds are described below.
AB - Aeromonas veronii strain A134 was isolated from Microcystis aeruginosa colonies collected from Lake Kinneret (Sea of Galilee), Israel. The Aeromonas culture media inhibited the growth of M. aeruginosa (strain MGK). The crude extract of a large-scale culture of A. veronii A134 was separated in a few chromatographic steps to yield three new secondary metabolites, 9-chlorolumichrome (1), veronimide (2) and veronipyrazine (3), along with a known lumichrome and several known diketopiperazines. The structures of the new compounds were established by analyses of the data from 1D and 2D NMR experiments and HRMS data of the compounds, as well as a single-crystal X-ray analysis of synthetic 1. The structure elucidation and proposed biogenesis of the new compounds are described below.
KW - Aeromonas veronii
KW - Microcystis aeruginosa
KW - Secondary metabolites
UR - http://www.scopus.com/inward/record.url?scp=85068498640&partnerID=8YFLogxK
U2 - 10.3390/metabo9060110
DO - 10.3390/metabo9060110
M3 - Article
AN - SCOPUS:85068498640
SN - 2218-1989
VL - 9
JO - Metabolites
JF - Metabolites
IS - 6
M1 - 110
ER -
