TY - CHAP
T1 - Segmental-Dependent Drug Absorption and Delivery:
T2 - The Intestinal Tract
AU - Wolk, Omri
AU - Dahan, Arik
PY - 2014
Y1 - 2014
N2 - The intestinal tract is a long and complex organ, with significantly variable characteristics throughout it. It is broadly divided to several segments: the small intestine, which is subdivided to duodenum, jejunum, and ileum, and the colon. Each segment has its own unique environment. Conditions in each segment are dependent on a multitude of factors. This chapter surveys three such factors: environmental pH values, transporter expression levels, and CYP3A4 expression. Their influence on drug absorption is discussed, and technologies to exploit them for optimization of absorption are reviewed. In conclusion, segment-specific drug absorption and delivery is a highly important research field; a thorough understanding of the determinants of intestinal environment, considering the whole of the human intestine, is crucial for successful targeting of drugs to specific intestinal regions and exploitation of the variable intestinal conditions for better drug delivery and therapeutic effect.
AB - The intestinal tract is a long and complex organ, with significantly variable characteristics throughout it. It is broadly divided to several segments: the small intestine, which is subdivided to duodenum, jejunum, and ileum, and the colon. Each segment has its own unique environment. Conditions in each segment are dependent on a multitude of factors. This chapter surveys three such factors: environmental pH values, transporter expression levels, and CYP3A4 expression. Their influence on drug absorption is discussed, and technologies to exploit them for optimization of absorption are reviewed. In conclusion, segment-specific drug absorption and delivery is a highly important research field; a thorough understanding of the determinants of intestinal environment, considering the whole of the human intestine, is crucial for successful targeting of drugs to specific intestinal regions and exploitation of the variable intestinal conditions for better drug delivery and therapeutic effect.
U2 - 10.1007/978-1-4614-9434-8_16
DO - 10.1007/978-1-4614-9434-8_16
M3 - Chapter
SN - 9781461494331
T3 - Advances in Delivery Science and Technology
SP - 343
EP - 357
BT - Focal Controlled Drug Delivery
PB - Springer New York
ER -