Abstract
Efficient and highly selective catalytic conditions for the aerobic autoxidation of methylarenes to benzaldehydes, based on N-hydroxyphthalimide (NHPI) and cobalt(II) acetate in 1,1,1,3,3,3-hexafluoropropan-2-ol (HFIP), were developed. The sustainable conditions enable a multigram scale preparation of benzaldehyde derivatives in high efficiency and with excellent chemoselectivity (up to 99 % conversion and 98 % selectivity).
Original language | English |
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Pages (from-to) | 5912-5915 |
Number of pages | 4 |
Journal | Angewandte Chemie - International Edition |
Volume | 56 |
Issue number | 21 |
DOIs | |
State | Published - 15 May 2017 |
Keywords
- C−H activation
- aerobic oxidation
- benzaldehydes
- catalysis
- solvent effects
ASJC Scopus subject areas
- Catalysis
- General Chemistry