Selective Aerobic Oxidation of Methylarenes to Benzaldehydes Catalyzed by N-Hydroxyphthalimide and Cobalt(II) Acetate in Hexafluoropropan-2-ol

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Abstract

Efficient and highly selective catalytic conditions for the aerobic autoxidation of methylarenes to benzaldehydes, based on N-hydroxyphthalimide (NHPI) and cobalt(II) acetate in 1,1,1,3,3,3-hexafluoropropan-2-ol (HFIP), were developed. The sustainable conditions enable a multigram scale preparation of benzaldehyde derivatives in high efficiency and with excellent chemoselectivity (up to 99 % conversion and 98 % selectivity).

Original languageEnglish
Pages (from-to)5912-5915
Number of pages4
JournalAngewandte Chemie - International Edition
Volume56
Issue number21
DOIs
StatePublished - 15 May 2017

Keywords

  • C−H activation
  • aerobic oxidation
  • benzaldehydes
  • catalysis
  • solvent effects

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