Selective detection of catecholamines by synthetic receptors embedded in chromatic polydiacetylene vesicles

Sofiya Kolusheva; Oliver Molt; Michael Herm; Thomas Schrader; Raz Jelinek

doi:10.1021/ja052436q

Selective detection of catecholamines by synthetic receptors embedded in chromatic polydiacetylene vesicles

Sofiya Kolusheva, Oliver Molt, Michael Herm, Thomas Schrader, Raz Jelinek

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97 Scopus citations

Abstract

A new detection scheme for catecholamines was constructed through embedding synthetic receptors within vesicles comprising phospholipids and polydiacetylene. Fluorescence emission of the polydiacetylene was induced through specific interactions between the soluble ligands and the vesicle-incorporated hosts. The system demonstrated remarkable selectivity among structurally similar ligands and achieved much lower detection thresholds compared to that of other reported catecholamine sensors. The chromatic assembly provides a generic route for high sensitivity detection of ligand-receptor interactions.

Original language	English
Pages (from-to)	10000-10001
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	127
Issue number	28
DOIs	https://doi.org/10.1021/ja052436q
State	Published - 20 Jul 2005

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja052436q

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abstract = "A new detection scheme for catecholamines was constructed through embedding synthetic receptors within vesicles comprising phospholipids and polydiacetylene. Fluorescence emission of the polydiacetylene was induced through specific interactions between the soluble ligands and the vesicle-incorporated hosts. The system demonstrated remarkable selectivity among structurally similar ligands and achieved much lower detection thresholds compared to that of other reported catecholamine sensors. The chromatic assembly provides a generic route for high sensitivity detection of ligand-receptor interactions.",

author = "Sofiya Kolusheva and Oliver Molt and Michael Herm and Thomas Schrader and Raz Jelinek",

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AU - Kolusheva, Sofiya

AU - Molt, Oliver

AU - Herm, Michael

AU - Schrader, Thomas

AU - Jelinek, Raz

PY - 2005/7/20

Y1 - 2005/7/20

N2 - A new detection scheme for catecholamines was constructed through embedding synthetic receptors within vesicles comprising phospholipids and polydiacetylene. Fluorescence emission of the polydiacetylene was induced through specific interactions between the soluble ligands and the vesicle-incorporated hosts. The system demonstrated remarkable selectivity among structurally similar ligands and achieved much lower detection thresholds compared to that of other reported catecholamine sensors. The chromatic assembly provides a generic route for high sensitivity detection of ligand-receptor interactions.

AB - A new detection scheme for catecholamines was constructed through embedding synthetic receptors within vesicles comprising phospholipids and polydiacetylene. Fluorescence emission of the polydiacetylene was induced through specific interactions between the soluble ligands and the vesicle-incorporated hosts. The system demonstrated remarkable selectivity among structurally similar ligands and achieved much lower detection thresholds compared to that of other reported catecholamine sensors. The chromatic assembly provides a generic route for high sensitivity detection of ligand-receptor interactions.

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Selective detection of catecholamines by synthetic receptors embedded in chromatic polydiacetylene vesicles

Abstract

ASJC Scopus subject areas

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