TY - JOUR
T1 - Selective IgE deficiency and cardiovascular diseases
AU - Magen, Eli
AU - Mishal, Joseph
AU - Vardy, Daniel
N1 - Publisher Copyright:
Copyright © 2015, OceanSide Publications, Inc., U.S.A.
PY - 2015/5/1
Y1 - 2015/5/1
N2 - Selective immunoglobulin E (IgE) deficiency (IgED) is defined as serum levels of IgE more than or equal to 2 kIU/L and is associated with immune dysregulation and autoimmunity. This study aimed to investigate a prevalence of atherosclerotic cardiovascular disease (ASCVD) in population with IgED. Within the electronic patient record (EPR) database of Leumit Health Care Services (LHS) in Israel, data capture was performed using IBM Cognos 10.1.1 BI Report Studio software. The case samples were drawn from the full study population (n = 18,487), having any allergy-related symptoms and/or those requesting antiallergy medications and performed serum total IgE measurement during 2012 at LHS. All subjects aged more than or equal to 40 years old, with serum total IgE less than 2 kIU/L were included in case group. Control group was randomly sampled from the remained subjects, with a case-control ratio of 10 controls for each case (1:10). The comorbid cardiovascular diseases during less than or equal to 10 years before serum total IgE testing were identified and retrieved using specific International Classification of Diseases, 9th Revision, Clinical Modification diagnostic codes. There were 103 in case and 1030 subjects in control group. Compared with control group patients, the case group had significantly more arterial hypertension [34 (37.7%) versus 187 (18.2%), p < 0.001], ischemic heart disease (IHD) [26 (25.2%) versus 87 (8.4%), p <0.001], carotid stenosis [5 (4.9%) versus 7 (0.7%), p< 0.003], cerebrovascular disease (CVD) [3 (2.9%) versus 5 (0.5%), p< 0.029], and peripheral vascular disease (PVD) [4 (3.9%) versus 9 (0.9%), p= 0.024]. IgED is associated with higher prevalence of arterial hypertension and ASCVD.
AB - Selective immunoglobulin E (IgE) deficiency (IgED) is defined as serum levels of IgE more than or equal to 2 kIU/L and is associated with immune dysregulation and autoimmunity. This study aimed to investigate a prevalence of atherosclerotic cardiovascular disease (ASCVD) in population with IgED. Within the electronic patient record (EPR) database of Leumit Health Care Services (LHS) in Israel, data capture was performed using IBM Cognos 10.1.1 BI Report Studio software. The case samples were drawn from the full study population (n = 18,487), having any allergy-related symptoms and/or those requesting antiallergy medications and performed serum total IgE measurement during 2012 at LHS. All subjects aged more than or equal to 40 years old, with serum total IgE less than 2 kIU/L were included in case group. Control group was randomly sampled from the remained subjects, with a case-control ratio of 10 controls for each case (1:10). The comorbid cardiovascular diseases during less than or equal to 10 years before serum total IgE testing were identified and retrieved using specific International Classification of Diseases, 9th Revision, Clinical Modification diagnostic codes. There were 103 in case and 1030 subjects in control group. Compared with control group patients, the case group had significantly more arterial hypertension [34 (37.7%) versus 187 (18.2%), p < 0.001], ischemic heart disease (IHD) [26 (25.2%) versus 87 (8.4%), p <0.001], carotid stenosis [5 (4.9%) versus 7 (0.7%), p< 0.003], cerebrovascular disease (CVD) [3 (2.9%) versus 5 (0.5%), p< 0.029], and peripheral vascular disease (PVD) [4 (3.9%) versus 9 (0.9%), p= 0.024]. IgED is associated with higher prevalence of arterial hypertension and ASCVD.
UR - http://www.scopus.com/inward/record.url?scp=84932150570&partnerID=8YFLogxK
U2 - 10.2500/aap.2015.36.3825
DO - 10.2500/aap.2015.36.3825
M3 - Article
C2 - 25976439
AN - SCOPUS:84932150570
SN - 1088-5412
VL - 36
SP - 225
EP - 229
JO - Allergy and Asthma Proceedings
JF - Allergy and Asthma Proceedings
IS - 3
ER -