Selective modulation of cellular voltage-dependent calcium channels by hyperbaric pressure-a suggested HPNS partial mechanism

Ben Aviner; Gideon Gradwohl; Merav Mor Aviner; Shiri Levy; Yoram Grossman

doi:10.3389/fncel.2014.00136

Selective modulation of cellular voltage-dependent calcium channels by hyperbaric pressure-a suggested HPNS partial mechanism

Ben Aviner, Gideon Gradwohl, Merav Mor Aviner, Shiri Levy, Yoram Grossman

Physiology and Cell Biology

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Professional deep sea divers experience motor and cognitive impairment, known as High Pressure Neurological Syndrome (HPNS), when exposed to pressures of 100 msw (1.1 MPa) and above, considered to be the result of synaptic transmission alteration. Previous studies have indicated modulation of presynaptic Ca²⁺ currents at high pressure. We directly measured for the first time pressure effects on the currents of voltage dependent Ca²⁺ channels (VDCCs) expressed in Xenopus oocytes. Pressure selectivity augmented the current in CaV1.2 and depressed it in Ca_V3.2 channels. Pressure application also affected the channels' kinetics, such as τRise, τDecay. Pressure modulation of VDCCs seems to play an important role in generation of HPNS signs and symptoms.

Original language	English
Article number	136
Journal	Frontiers in Cellular Neuroscience
Volume	8
Issue number	MAY
DOIs	https://doi.org/10.3389/fncel.2014.00136
State	Published - 27 May 2014

Keywords

Conformational change
High pressure
High pressure neurological syndrome
Hyperbaric helium pressure
Synaptic transmission
Voltage dependency
Voltage dependent calcium channels

ASJC Scopus subject areas

Cellular and Molecular Neuroscience

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10.3389/fncel.2014.00136

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abstract = "Professional deep sea divers experience motor and cognitive impairment, known as High Pressure Neurological Syndrome (HPNS), when exposed to pressures of 100 msw (1.1 MPa) and above, considered to be the result of synaptic transmission alteration. Previous studies have indicated modulation of presynaptic Ca2+ currents at high pressure. We directly measured for the first time pressure effects on the currents of voltage dependent Ca2+ channels (VDCCs) expressed in Xenopus oocytes. Pressure selectivity augmented the current in CaV1.2 and depressed it in CaV3.2 channels. Pressure application also affected the channels' kinetics, such as τRise, τDecay. Pressure modulation of VDCCs seems to play an important role in generation of HPNS signs and symptoms.",

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AU - Gradwohl, Gideon

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AU - Grossman, Yoram

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Selective modulation of cellular voltage-dependent calcium channels by hyperbaric pressure-a suggested HPNS partial mechanism

Abstract

Keywords

ASJC Scopus subject areas

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