Selective recognition of ATP by multivalent nano-assemblies of bisimidazolium amphiphiles through “turn-on” fluorescence response

Rakesh Biswas, Surya Ghosh, Shubhra Kanti Bhaumik, Supratim Banerjee

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Bisimidazolium receptors, tagged with chromophoric pyrene at one end and linked to an n-alkyl chain at the other, underwent self-assembly in aqueous media depending on the length of the alkyl segment. The amphiphilic derivatives having n-decyl or longer chains, formed nano-assemblies with cyanic-green emission resulting from the stacked pyrene chromophores in the aggregates. The presence of positive surface charges on the multivalent aggregates led to ATP binding which was accompanied by a significant increase in the excimeric emission intensity. This provided a convenient way of monitoring ATP binding in a “turn-on” mode and an efficient detection of ATP was achieved in aqueous buffer and also in buffer containing 150 mM NaCl at physiological pH value. Furthermore, the multivalent aggregates demonstrated a significant selectivity in ATP detection over ADP, AMP and pyrophosphate.

Original languageEnglish
Pages (from-to)2728-2738
Number of pages11
JournalBeilstein Journal of Organic Chemistry
Volume16
DOIs
StatePublished - 10 Nov 2020
Externally publishedYes

Keywords

  • ATP
  • Amphiphile
  • Excimer
  • Multivalency
  • Self-assembly

ASJC Scopus subject areas

  • Organic Chemistry

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