Selective serotonin reuptake inhibitors (SSRIs) inhibit insulin secretion and action in pancreatic β cells

Roi Isaac; Sigalit Boura-Halfon; Diana Gurevitch; Alla Shainskaya; Yechiel Levkovitz; Yehiel Zick

doi:10.1074/jbc.M112.408641

Selective serotonin reuptake inhibitors (SSRIs) inhibit insulin secretion and action in pancreatic β cells

Roi Isaac
, Sigalit Boura-Halfon
, Diana Gurevitch
, Alla Shainskaya
, Yechiel Levkovitz
, Yehiel Zick

Research output: Contribution to journal › Article › peer-review

78 Scopus citations

Abstract

Background: Selective serotonin reuptake inhibitors (SSRIs) are used for the treatment of mood and anxiety disorders. Results: SSRIs inhibit insulin action and secretion, promote the unfolded protein response, and induce apoptosis of pancreatic β cells. Conclusion: SSRIs inhibit insulin signaling and beta cell function. Significance: SSRIs might accelerate the transition from an insulin-resistant state to overt diabetes.

Original language	English
Pages (from-to)	5682-5693
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	288
Issue number	8
DOIs	https://doi.org/10.1074/jbc.M112.408641
State	Published - 22 Feb 2013
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1074/jbc.M112.408641

Cite this

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title = "Selective serotonin reuptake inhibitors (SSRIs) inhibit insulin secretion and action in pancreatic β cells",

abstract = "Background: Selective serotonin reuptake inhibitors (SSRIs) are used for the treatment of mood and anxiety disorders. Results: SSRIs inhibit insulin action and secretion, promote the unfolded protein response, and induce apoptosis of pancreatic β cells. Conclusion: SSRIs inhibit insulin signaling and beta cell function. Significance: SSRIs might accelerate the transition from an insulin-resistant state to overt diabetes.",

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AU - Isaac, Roi

AU - Boura-Halfon, Sigalit

AU - Gurevitch, Diana

AU - Shainskaya, Alla

AU - Levkovitz, Yechiel

AU - Zick, Yehiel

PY - 2013/2/22

Y1 - 2013/2/22

N2 - Background: Selective serotonin reuptake inhibitors (SSRIs) are used for the treatment of mood and anxiety disorders. Results: SSRIs inhibit insulin action and secretion, promote the unfolded protein response, and induce apoptosis of pancreatic β cells. Conclusion: SSRIs inhibit insulin signaling and beta cell function. Significance: SSRIs might accelerate the transition from an insulin-resistant state to overt diabetes.

AB - Background: Selective serotonin reuptake inhibitors (SSRIs) are used for the treatment of mood and anxiety disorders. Results: SSRIs inhibit insulin action and secretion, promote the unfolded protein response, and induce apoptosis of pancreatic β cells. Conclusion: SSRIs inhibit insulin signaling and beta cell function. Significance: SSRIs might accelerate the transition from an insulin-resistant state to overt diabetes.

UR - https://www.scopus.com/pages/publications/84874297756

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JO - Journal of Biological Chemistry

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Selective serotonin reuptake inhibitors (SSRIs) inhibit insulin secretion and action in pancreatic β cells

Abstract

ASJC Scopus subject areas

UN SDGs

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