Self-programmed nanovesicle to nanofiber transformation of a dipeptide appended bolaamphiphile and its dose dependent cytotoxic behaviour

Indrajit Maity, Hamendra S. Parmar, Dnyaneshwar B. Rasale, Apurba K. Das

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Nanostructural transition of a small peptide bolaamphiphile via molecular self-assembly is a challenging task. Here, we report the self-programmed morphological transformation from nanovesicles to nanofibers of a smart peptide bolaamphiphile in its self-assembling hydrogel state. The nanostructural transition occurs based on the structural continuity of the β-sheet structures. Spectroscopic studies confirmed the different molecular arrangements of the two different nanostructures. Furthermore, the smart bolaamphiphile shows a dose-dependent cytotoxicity and cell-proliferation behaviour. This journal is

Original languageEnglish
Pages (from-to)5272-5279
Number of pages8
JournalJournal of Materials Chemistry B
Volume2
Issue number32
DOIs
StatePublished - 28 Aug 2014
Externally publishedYes

ASJC Scopus subject areas

  • General Chemistry
  • Biomedical Engineering
  • General Materials Science

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