Self-replicating amphiphilic β-sheet peptides

Boris Rubinov; Nathaniel Wagner; Hanna Rapaport; Gonen Ashkenasy

doi:10.1002/anie.200902790

Self-replicating amphiphilic β-sheet peptides

Boris Rubinov, Nathaniel Wagner, Hanna Rapaport, Gonen Ashkenasy

Research output: Contribution to journal › Article › peer-review

123 Scopus citations

Abstract

Simple peptides can do that too: Synthetic amphiphilic peptides 1, formed of electrophilic (E) and nucleophilic (N) precursors, are close analogues of the Glu-(Phe-Glu)_n molecules. The peptides form soluble one-dimensional β-sheet aggregates in water (see picture), and serve to significantly accelerate chemical ligation and self-replication.

Original language	English
Pages (from-to)	6683-6686
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	48
Issue number	36
DOIs	https://doi.org/10.1002/anie.200902790
State	Published - 24 Aug 2009

Keywords

Origins of life
Peptides
Self-replication
Systems chemistry
β sheet structures

ASJC Scopus subject areas

Catalysis
General Chemistry

Access to Document

10.1002/anie.200902790

Cite this

@article{f3588bdff50d465a99b1a86b7e1e1b54,

title = "Self-replicating amphiphilic β-sheet peptides",

abstract = "Simple peptides can do that too: Synthetic amphiphilic peptides 1, formed of electrophilic (E) and nucleophilic (N) precursors, are close analogues of the Glu-(Phe-Glu)n molecules. The peptides form soluble one-dimensional β-sheet aggregates in water (see picture), and serve to significantly accelerate chemical ligation and self-replication.",

keywords = "Origins of life, Peptides, Self-replication, Systems chemistry, β sheet structures",

author = "Boris Rubinov and Nathaniel Wagner and Hanna Rapaport and Gonen Ashkenasy",

year = "2009",

month = aug,

day = "24",

doi = "10.1002/anie.200902790",

language = "English",

volume = "48",

pages = "6683--6686",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "36",

}

TY - JOUR

T1 - Self-replicating amphiphilic β-sheet peptides

AU - Rubinov, Boris

AU - Wagner, Nathaniel

AU - Rapaport, Hanna

AU - Ashkenasy, Gonen

PY - 2009/8/24

Y1 - 2009/8/24

N2 - Simple peptides can do that too: Synthetic amphiphilic peptides 1, formed of electrophilic (E) and nucleophilic (N) precursors, are close analogues of the Glu-(Phe-Glu)n molecules. The peptides form soluble one-dimensional β-sheet aggregates in water (see picture), and serve to significantly accelerate chemical ligation and self-replication.

AB - Simple peptides can do that too: Synthetic amphiphilic peptides 1, formed of electrophilic (E) and nucleophilic (N) precursors, are close analogues of the Glu-(Phe-Glu)n molecules. The peptides form soluble one-dimensional β-sheet aggregates in water (see picture), and serve to significantly accelerate chemical ligation and self-replication.

KW - Origins of life

KW - Peptides

KW - Self-replication

KW - Systems chemistry

KW - β sheet structures

UR - http://www.scopus.com/inward/record.url?scp=70349932857&partnerID=8YFLogxK

U2 - 10.1002/anie.200902790

DO - 10.1002/anie.200902790

M3 - Article

AN - SCOPUS:70349932857

SN - 1433-7851

VL - 48

SP - 6683

EP - 6686

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 36

ER -

Self-replicating amphiphilic β-sheet peptides

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this