TY - JOUR
T1 - Self-stabilizing colonic capsule endoscopy
T2 - Pilot study of acute canine models
AU - Filip, Dobromir
AU - Yadid-Pecht, Orly
AU - Andrews, Christopher N.
AU - Mintchev, Martin P.
N1 - Funding Information:
Manuscript received May 02, 2011; revised July 18, 2011; accepted July 21, 2011. Date of publication July 29, 2011; date of current version December 02, 2011. This work was supported in part by Sandhill Scientific, USA and in part by Intromedic, Inc., Korea. Asterisk indicates corresponding author. D. Filip and O. Yadid-Pecht are with the Department of Electrical and Computer Engineering, University of Calgary, Calgary, AB, T2N 1N4 Canada. C. N. Andrews is with the Department of Medicine, Division of Gastroenterology, University of Calgary, Calgary, AB, T2N 1N4 Canada. *M. P. Mintchev is with the Department of Electrical and Computer Engineering, University of Calgary, Calgary AB, T2N 1N4 Canada (e-mail: mintchev@enel.ucalgary.ca). Digital Object Identifier 10.1109/TMI.2011.2163165
PY - 2011/12/1
Y1 - 2011/12/1
N2 - Video capsule endoscopy (VCE) is a noninvasive method for examining the gastrointestinal tract which has been successful in small intestine studies. Recently, VCE has been attempted in the colon. However, the capsule often tumbles in the wider colonic lumen, resulting in missed regions. Self-stabilizing VCE is a novel method to visualize the colon without tumbling. The aim of the present study was to comparatively quantify the effect of stabilization of a commercially available nonmodified capsule endoscope (CE) MiroCam and its modified self-stabilizing version in acute canine experiments. Two customized MiroCam CEs were reduced in volume at the nonimaging back-end to allow the attachment of a self-expanding, biocompatible stabilizing device. Four mongrel dogs underwent laparotomy and exteriorization of a 15-cm segment of the proximal descending colon. A single CE, either self-stabilizing or nonmodified was inserted through an incision into the lumen of the colon followed by pharmacologically induced colonic peristalsis. The inserted capsule was propelled distally through the colon and expelled naturally through the anus. Novel signal processing method was developed to quantify the video stabilization based on camera tracking a predetermined target point (locale). The average locale trajectory, the average radius movement of the locale, and the maximum rate of change of the locale for sequential images were significantly lower for the stabilized capsules compared to the nonstabilized ones $({ p} < 0.05)$. The feasibility of self-stabilized capsule endoscopy has been demonstrated in acute canine experiments.
AB - Video capsule endoscopy (VCE) is a noninvasive method for examining the gastrointestinal tract which has been successful in small intestine studies. Recently, VCE has been attempted in the colon. However, the capsule often tumbles in the wider colonic lumen, resulting in missed regions. Self-stabilizing VCE is a novel method to visualize the colon without tumbling. The aim of the present study was to comparatively quantify the effect of stabilization of a commercially available nonmodified capsule endoscope (CE) MiroCam and its modified self-stabilizing version in acute canine experiments. Two customized MiroCam CEs were reduced in volume at the nonimaging back-end to allow the attachment of a self-expanding, biocompatible stabilizing device. Four mongrel dogs underwent laparotomy and exteriorization of a 15-cm segment of the proximal descending colon. A single CE, either self-stabilizing or nonmodified was inserted through an incision into the lumen of the colon followed by pharmacologically induced colonic peristalsis. The inserted capsule was propelled distally through the colon and expelled naturally through the anus. Novel signal processing method was developed to quantify the video stabilization based on camera tracking a predetermined target point (locale). The average locale trajectory, the average radius movement of the locale, and the maximum rate of change of the locale for sequential images were significantly lower for the stabilized capsules compared to the nonstabilized ones $({ p} < 0.05)$. The feasibility of self-stabilized capsule endoscopy has been demonstrated in acute canine experiments.
KW - Colon
KW - gastrointestinal tract
KW - imaging
KW - video capsule endoscopy
UR - http://www.scopus.com/inward/record.url?scp=82355161990&partnerID=8YFLogxK
U2 - 10.1109/TMI.2011.2163165
DO - 10.1109/TMI.2011.2163165
M3 - Article
C2 - 21803680
AN - SCOPUS:82355161990
SN - 0278-0062
VL - 30
SP - 2115
EP - 2125
JO - IEEE Transactions on Medical Imaging
JF - IEEE Transactions on Medical Imaging
IS - 12
M1 - 5963723
ER -