Semi-automated visualization and analysis of trends: A “Savant” for facilitating antimicrobial stewardship using antistaphylococcal resistance and consumption as a prototype

Robert J. Clifford, Uzo Chukwuma, Michael E. Sparks, Douglas Richesson, Charlotte V. Neumann, Paige E. Waterman, Jacob Moran-Gilad, Michael D. Julius, Mary K. Hinkle, Emil P. Lesho

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: Governments and health care regulators now require hospitals and nursing homes to establish programs to monitor and report antimicrobial consumption and resistance. However, additional resources were not provided. We sought to develop an approach for monitoring antimicrobial resistance and consumption that health care systems can implement with minimal added costs or modifications to existing diagnostic and informatics infrastructure. Methods: Using (1) the electronic laboratory information system of a nationwide managed care network, (2) the 3 most widely used commercial microbiology diagnostic platforms, and (3) Staphylococcus aureus, one of the most common causes of infections worldwide, as a prototype, we validated the approach dubbed “SAVANT” for Semi-Automated Visualization and ANalysis of Trends. SAVANT leverages 3 analytical methods (time series analysis, the autoregressive integrated moving average, and generalized linear regression) on either commercial or open source software to report trends in antistaphylococcal use and resistance. Results: All laboratory results from January 2010 through December 2015 from an annual average of 9.2 million health care beneficiaries were queried. Inpatient and outpatient prescription rates were calculated for 8 key antistaphylococcal compounds. Trends and relationships of antistaphylococcal consumption and resistance among 81 840 unique S. aureus isolates from >6.5 million cultures were revealed. Conclusions: Using existing or freely available resources, SAVANT was successfully implemented across a complex and geographically dispersed 280-hospital network, bridging a critical gap between medical informatics, large-scale data analytics, and mandatory reporting of health care quality metrics.

Original languageEnglish
JournalOpen Forum Infectious Diseases
Volume5
Issue number4
DOIs
StatePublished - 1 Apr 2018

Keywords

  • Antibiotic consumption and resistance
  • Antimicrobial stewardship
  • Informatics
  • Staphylococcus aureus

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