TY - JOUR
T1 - Semiconservative replication, genetic repair, and many-gened genomes
T2 - Extending the quasispecies paradigm to living systems
AU - Tannenbaum, Emmanuel
AU - Shakhnovich, Eugene I.
N1 - Funding Information:
This research was supported by the National Institutes of Health. The authors thank collaborators Eric J. Deeds, Yisroel Brumer, and James L. Sherley, as well as Brian N. Dominy, Igor N. Berezovsky, William W. Chen, Huseyin Kaya, and Jae-Shick Yang for helpful conversations.
PY - 2005/12/1
Y1 - 2005/12/1
N2 - Quasispecies theory has emerged as an important tool for modeling the evolutionary dynamics of biological systems. We review recent advances in the field, with an emphasis on the quasispecies dynamics of semiconservatively replicating genomes. Applications to cancer and adult stem cell growth are discussed. Additional topics, such as genetic repair and many-gene genomes, are covered as well.
AB - Quasispecies theory has emerged as an important tool for modeling the evolutionary dynamics of biological systems. We review recent advances in the field, with an emphasis on the quasispecies dynamics of semiconservatively replicating genomes. Applications to cancer and adult stem cell growth are discussed. Additional topics, such as genetic repair and many-gene genomes, are covered as well.
KW - Catastrophe
KW - Error
KW - Evolution
KW - Fitness landscapes
KW - Quasispecies
KW - Semiconservative
KW - Stem cells
UR - http://www.scopus.com/inward/record.url?scp=28844456875&partnerID=8YFLogxK
U2 - 10.1016/j.plrev.2005.08.001
DO - 10.1016/j.plrev.2005.08.001
M3 - Review article
AN - SCOPUS:28844456875
SN - 1571-0645
VL - 2
SP - 290
EP - 317
JO - Physics of Life Reviews
JF - Physics of Life Reviews
IS - 4
ER -
