Abstract
Quasispecies theory has emerged as an important tool for modeling the evolutionary dynamics of biological systems. We review recent advances in the field, with an emphasis on the quasispecies dynamics of semiconservatively replicating genomes. Applications to cancer and adult stem cell growth are discussed. Additional topics, such as genetic repair and many-gene genomes, are covered as well.
Original language | English |
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Pages (from-to) | 290-317 |
Number of pages | 28 |
Journal | Physics of Life Reviews |
Volume | 2 |
Issue number | 4 |
DOIs | |
State | Published - 1 Dec 2005 |
Keywords
- Catastrophe
- Error
- Evolution
- Fitness landscapes
- Quasispecies
- Semiconservative
- Stem cells
ASJC Scopus subject areas
- General Agricultural and Biological Sciences
- General Physics and Astronomy
- Artificial Intelligence