Sensitivity booster for mass detection enables unambiguous analysis of peptides, proteins, antibodies, and protein bioconjugates

Rohith Singudas, Neelesh C. Reddy, Vishal Rai

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

A chemical tag enhances peptide detection by multiple orders in mass spectrometry. The substantial improvement in the peptide mapping along with simplified and enhanced fragmentation pattern enables the unambiguous sequencing of a protein and antibody. The chemoselective sensitivity booster provides a tool for remarkably improved analysis of protein bioconjugates.

Original languageEnglish
Pages (from-to)9979-9982
Number of pages4
JournalChemical Communications
Volume55
Issue number67
DOIs
StatePublished - 1 Jan 2019
Externally publishedYes

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