Sensitivity booster for mass detection enables unambiguous analysis of peptides, proteins, antibodies, and protein bioconjugates

Rohith Singudas; Neelesh C. Reddy; Vishal Rai

doi:10.1039/c9cc03424b

Sensitivity booster for mass detection enables unambiguous analysis of peptides, proteins, antibodies, and protein bioconjugates

Rohith Singudas, Neelesh C. Reddy, Vishal Rai

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

A chemical tag enhances peptide detection by multiple orders in mass spectrometry. The substantial improvement in the peptide mapping along with simplified and enhanced fragmentation pattern enables the unambiguous sequencing of a protein and antibody. The chemoselective sensitivity booster provides a tool for remarkably improved analysis of protein bioconjugates.

Original language	English
Pages (from-to)	9979-9982
Number of pages	4
Journal	Chemical Communications
Volume	55
Issue number	67
DOIs	https://doi.org/10.1039/c9cc03424b
State	Published - 1 Jan 2019
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c9cc03424b

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title = "Sensitivity booster for mass detection enables unambiguous analysis of peptides, proteins, antibodies, and protein bioconjugates",

abstract = "A chemical tag enhances peptide detection by multiple orders in mass spectrometry. The substantial improvement in the peptide mapping along with simplified and enhanced fragmentation pattern enables the unambiguous sequencing of a protein and antibody. The chemoselective sensitivity booster provides a tool for remarkably improved analysis of protein bioconjugates.",

author = "Rohith Singudas and Reddy, {Neelesh C.} and Vishal Rai",

note = "Publisher Copyright: {\textcopyright} 2019 The Royal Society of Chemistry.",

year = "2019",

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doi = "10.1039/c9cc03424b",

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T1 - Sensitivity booster for mass detection enables unambiguous analysis of peptides, proteins, antibodies, and protein bioconjugates

AU - Singudas, Rohith

AU - Reddy, Neelesh C.

AU - Rai, Vishal

PY - 2019/1/1

Y1 - 2019/1/1

N2 - A chemical tag enhances peptide detection by multiple orders in mass spectrometry. The substantial improvement in the peptide mapping along with simplified and enhanced fragmentation pattern enables the unambiguous sequencing of a protein and antibody. The chemoselective sensitivity booster provides a tool for remarkably improved analysis of protein bioconjugates.

AB - A chemical tag enhances peptide detection by multiple orders in mass spectrometry. The substantial improvement in the peptide mapping along with simplified and enhanced fragmentation pattern enables the unambiguous sequencing of a protein and antibody. The chemoselective sensitivity booster provides a tool for remarkably improved analysis of protein bioconjugates.

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U2 - 10.1039/c9cc03424b

DO - 10.1039/c9cc03424b

M3 - Article

C2 - 31367719

AN - SCOPUS:85070830140

SN - 1359-7345

VL - 55

SP - 9979

EP - 9982

JO - Chemical Communications

JF - Chemical Communications

IS - 67

ER -

Sensitivity booster for mass detection enables unambiguous analysis of peptides, proteins, antibodies, and protein bioconjugates

Abstract

ASJC Scopus subject areas

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