Sequence dependent rigidity of single stranded DNA

Noel L. Goddard, Grégoire Bonnet, Oleg Krichevsky, Albert Libchaber

Research output: Contribution to journalArticlepeer-review

264 Scopus citations


The thermodynamic and kinetic properties of molecular conformation change in ssDNA were studied by measuring the steady state and fluctuations around thermal equilibrium. Focus was on the consequence of ssDNA stacking on its dynamics. Overall, the results provide strong evidence that ssDNA dynamics are so highly coupled to the sequence that is debatable whether the persistance length is a valid physical parameter at all.

Original languageEnglish
Pages (from-to)2400-2403
Number of pages4
JournalPhysical Review Letters
Issue number11
StatePublished - 1 Sep 2000
Externally publishedYes

ASJC Scopus subject areas

  • General Physics and Astronomy


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