Sequence dependent rigidity of single stranded DNA

Noel L. Goddard; Grégoire Bonnet; Oleg Krichevsky; Albert Libchaber

doi:10.1103/PhysRevLett.85.2400

Sequence dependent rigidity of single stranded DNA

Noel L. Goddard, Grégoire Bonnet, Oleg Krichevsky, Albert Libchaber

Research output: Contribution to journal › Article › peer-review

266 Scopus citations

Abstract

The thermodynamic and kinetic properties of molecular conformation change in ssDNA were studied by measuring the steady state and fluctuations around thermal equilibrium. Focus was on the consequence of ssDNA stacking on its dynamics. Overall, the results provide strong evidence that ssDNA dynamics are so highly coupled to the sequence that is debatable whether the persistance length is a valid physical parameter at all.

Original language	English
Pages (from-to)	2400-2403
Number of pages	4
Journal	Physical Review Letters
Volume	85
Issue number	11
DOIs	https://doi.org/10.1103/PhysRevLett.85.2400
State	Published - 1 Sep 2000
Externally published	Yes

ASJC Scopus subject areas

General Physics and Astronomy

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10.1103/PhysRevLett.85.2400

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title = "Sequence dependent rigidity of single stranded DNA",

abstract = "The thermodynamic and kinetic properties of molecular conformation change in ssDNA were studied by measuring the steady state and fluctuations around thermal equilibrium. Focus was on the consequence of ssDNA stacking on its dynamics. Overall, the results provide strong evidence that ssDNA dynamics are so highly coupled to the sequence that is debatable whether the persistance length is a valid physical parameter at all.",

author = "Goddard, {Noel L.} and Gr{\'e}goire Bonnet and Oleg Krichevsky and Albert Libchaber",

year = "2000",

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T1 - Sequence dependent rigidity of single stranded DNA

AU - Goddard, Noel L.

AU - Bonnet, Grégoire

AU - Krichevsky, Oleg

AU - Libchaber, Albert

PY - 2000/9/1

Y1 - 2000/9/1

N2 - The thermodynamic and kinetic properties of molecular conformation change in ssDNA were studied by measuring the steady state and fluctuations around thermal equilibrium. Focus was on the consequence of ssDNA stacking on its dynamics. Overall, the results provide strong evidence that ssDNA dynamics are so highly coupled to the sequence that is debatable whether the persistance length is a valid physical parameter at all.

AB - The thermodynamic and kinetic properties of molecular conformation change in ssDNA were studied by measuring the steady state and fluctuations around thermal equilibrium. Focus was on the consequence of ssDNA stacking on its dynamics. Overall, the results provide strong evidence that ssDNA dynamics are so highly coupled to the sequence that is debatable whether the persistance length is a valid physical parameter at all.

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U2 - 10.1103/PhysRevLett.85.2400

DO - 10.1103/PhysRevLett.85.2400

M3 - Article

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VL - 85

SP - 2400

EP - 2403

JO - Physical Review Letters

JF - Physical Review Letters

IS - 11

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Sequence dependent rigidity of single stranded DNA

Abstract

ASJC Scopus subject areas

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